Wipens Tablets

Adult dose

Usually administered orally, 2 tablets two times a day in the morning and before bedtime regardless of meals. 1) Gastric and duodenal ulcers Administer 2 tablets two times a day or 4 tablets once at bedtime. Especially for patients with duodenal ulcers, administering 4 tablets two times a day in the morning and at bedtime may achieve higher treatment rates. Dosage is the same for ulcers caused by NSAIDs or combination therapy to prevent gastric and duodenal ulcers due to long-term use of NSAIDs. Usually, conditions caused by NSAID use heal within 8 weeks, although healing time may occasionally be extended depending on the patient. For patients with recurring ulcers who have had excellent short-term therapy with this medication, 2 tablets should be administered once at bedtime as maintenance therapy. 2) Gastroesophageal reflux disease For 8 weeks, administer 2 tablets two times a day or 4 tablets once at bedtime. In severe cases of gastroesophageal reflux disease, the dosage may be increased to 4 tablets four times a day. 3) Zollinger-Ellison syndrome As an initial dose, start treatment with 2 tablets three times a day, and the dosage may be increased as necessary. In severe cases, under a doctor's direction, doses of up to 6 g of ranitidine may be given per day. 4) Peptic ulcer, acute stress ulcer, and upper gastrointestinal bleeding due to acute mucosal lesions Once oral administration is possible, switch from injection to oral administration, taking 2 tablets two times a day. 5) Pre-anesthetic administration (to prevent Mendelson’s syndrome) Administer 2 tablets 2 hours before anesthesia induction. It is also preferable to administer 2 tablets the night before the surgery.

This medication should not be used in patients undergoing dialysis treatment. Patients with a history of allergies to this medication or its components should also avoid taking it. Patients with a history of acute porphyria, a rare blood disorder, should not be administered this medication as it may trigger seizures. This medication should not be used in patients with impaired renal function or kidney diseases. It is also not recommended for patients who have undergone upper gastrointestinal surgery. Women who are pregnant or may become pregnant should not take this medication. It is advisable to avoid administering this drug to premature infants or newborns. Patients on a diet that restricts potassium intake should also avoid this medication. Patients with liver dysfunction should use this medication with caution, and those with a history of drug allergies should use it carefully. Elderly patients and those with a history of decreased renal function require caution. In cases where NSAIDs are used simultaneously, regular monitoring is needed, especially for elderly patients or those with a history of peptic ulcers. This medication may obscure the symptoms of gastric cancer, so it should be used with caution in patients with gastric ulcers or middle-aged patients with recent or changed dyspeptic symptoms, after confirming malignancy. Patients with helicobacter pylori-induced gastric or duodenal ulcers require eradication therapy. Patients in severe intensive care may be at risk of gastric stone formation, so caution is needed. Patients with hypophosphatemia should be careful, as the aluminum content of this medication may interfere with phosphate absorption. Patients who have difficulty swallowing should be cautious due to the risk of respiratory complications. While taking this medication, serious allergic reactions such as anaphylactic shock may occasionally occur; if abnormal symptoms arise, administration should be discontinued immediately and treated. If allergy symptoms such as skin rash, urticaria, angioedema, fever, or bronchospasm occur, discontinue use and consult a doctor. Blood tests may show decreased white blood cell or platelet counts; if such symptoms appear, discontinue taking the medication immediately. Symptoms of liver dysfunction may rarely occur, so if jaundice or hepatitis symptoms are noted, administration should be stopped immediately. Abnormalities in circulation such as cardiac arrhythmias or vasculitis have also been reported rarely, requiring caution. Gastrointestinal symptoms may include nausea, vomiting, constipation, diarrhea, and abdominal pain, and stool color may change, although this does not require special treatment. Neurological symptoms such as dizziness, drowsiness, confusion, seizures, insomnia, headache, and feeling of heaviness may also occur rarely, so inform a doctor if any abnormal symptoms are present. Endocrine symptoms such as gynecomastia, increased milk secretion, erectile dysfunction, and decreased libido have been reported very rarely. Myalgia and arthralgia may occur, and in serious cases, it may progress to rhabdomyolysis; therefore, discontinue use immediately if symptoms appear. Skin rashes, hair loss, and itching have been reported rarely, and the tongue may turn black but will recover naturally. To avoid long-term use, it is better to switch to another drug if there is no treatment effect. Elderly patients, those with chronic pulmonary disease, diabetics, and immunocompromised patients may be at increased risk of pneumonic infections while taking this medication, so caution is advised. If dizziness or drowsiness occurs after taking this medication, it is advisable to avoid driving or operating dangerous machinery. This medication may interact with other drugs; therefore, especially when taken with anticoagulants or some antibiotics and analgesics, consult a doctor or pharmacist. It is safer for pregnant or breastfeeding women not to take this medication. Safety in children has not been established, so it is advisable to avoid use whenever possible. This medication may affect certain clinical test results, so it is good to inform the healthcare providers at the time of testing. In case of overdose, treatment such as vomiting or gastric lavage may be necessary, and may be removable through hemodialysis.

Serious side effects

Shock (anaphylactic shock), urticaria, angioedema (severe swelling included), chest pain, bronchospasm (difficulty breathing), hypotension, skin rash, severe allergic reactions, agranulocytosis, pancytopenia, bone marrow suppression, aplastic anemia, aplastic anemia, acquired hemolytic anemia, jaundiced or non-jaundiced hepatitis (liver abnormalities), hepatic dysfunction, tachycardia, bradycardia, arrhythmia, vasculitis, dizziness, drowsiness, confusion, seizures

Mild side effects

• Skin rash
• urticaria
• angioedema
• fever
• bronchospasm
• hypotension
• chest pain
• agranulocytosis
• leukopenia
• thrombocytopenia

This medication should be stored in an airtight, sealed container and kept at a temperature between 1°C to 30°C at room temperature. Storing it this way helps maintain the medication's efficacy and prevents deterioration.

Appearance

White round film-coated tablets

Package unit

Bottle - 30 tablets/bottle, Bottle - 300 tablets/bottle