Ranidro Tablets (Ranitidine Hydrochloride)

Adult dose

As ranitidine, take 150 mg once, twice daily, orally in the morning and at bedtime. For gastric and duodenal ulcers, take 150 mg once orally, twice daily, or 300 mg once daily at bedtime. For patients with duodenal ulcers, 300 mg may be given twice daily in the morning and at bedtime. For prevention and treatment of ulcerations due to NSAID administration, the dosage is the same as described above. Typically, healing occurs within 4 weeks; diseases due to NSAID use usually heal within 8 weeks, though healing time may vary for some patients. For patients with recurrent ulcers where the short-term treatment has been effective, the maintenance therapy is 150 mg orally once a day at bedtime. For gastroesophageal reflux disease, take 150 mg orally twice daily for 8 weeks, or 300 mg once daily at bedtime. For severe gastroesophageal reflux disease, the dosage may increase to 150 mg four times daily. For Zollinger-Ellison syndrome, the initial dose is 150 mg taken three times daily, and the dosage may be increased as needed. In severe cases, doses up to 6 g daily may be administered according to a doctor's instructions. For upper gastrointestinal bleeding caused by peptic ulcers, acute stress ulcers, and acute gastric mucosal lesions, treatment usually begins with an injectable form and may be switched to oral dosing when feasible, taking 150 mg twice a day orally. For pre-anesthesia dosing (prevention of Mendelson's syndrome), 150 mg should be administered 2 hours before the induction of anesthesia. Administering 150 mg the night before surgery is also recommended. For improvement of gastric mucosal lesions (erosion, bleeding, redness, swelling) due to acute gastritis or acute exacerbation of chronic gastritis, one dose of 150 mg should be administered orally once a day at bedtime. For excessive gastric acid, heartburn, and belching: In patients aged 12 years and older, take 75 mg orally twice a day (for syrup only).

Child dose

For children aged 8 to 18 years, a single dose of 150 mg (2 mg per kg of body weight) may be administered up to twice a day.

This medication should not be used in patients who have previously shown allergic reactions to its components. Patients who have suffered from a rare blood disorder called acute porphyria should also use this medication with caution. Patients with impaired kidney function may require dosage adjustments as this medication can remain in the body for a longer period. Caution is also required when using this medication in patients with liver impairment. Patients with a history of drug allergies or elderly patients must exercise special care when taking this medication. Regular check-ups are necessary for patients taking NSAIDs, particularly elderly patients or those with a history of peptic ulcers. This medication may mask the symptoms of gastric cancer, so patients with gastric ulcers or new dyspeptic symptoms over the age of middle age should verify the malignancy before treatment. Patients with gastric or duodenal ulcers infected with Helicobacter pylori should receive bacterial eradication therapy concurrently. While rare, serious allergic reactions such as anaphylactic shock may occur during the course of treatment, and if any unusual symptoms appear, the use of this medication should be discontinued immediately. If allergic symptoms such as hives, rashes, difficulty in breathing, or hypotension occur, the medication should be stopped and medical advice should be sought. Blood-related side effects, such as leukopenia or thrombocytopenia, may occur infrequently, so testing is necessary if symptoms like fatigue, bleeding, or fever arise. Liver function impairment may occur, so if symptoms of jaundice, fatigue, or loss of appetite develop, medical personnel should be informed immediately. Rare symptoms of circulatory system abnormalities, such as cardiac arrhythmia or vasculitis, have also been reported, so care is needed. Gastrointestinal side effects such as constipation, nausea, abdominal pain may occur. Neuropsychiatric side effects such as dizziness, drowsiness, headache, or mental confusion may be present, thus it is advisable to avoid driving or operating dangerous machinery. If muscle pain or joint pain arises, inform a doctor and receive appropriate measures. Skin-related side effects such as rashes or hair loss may also occur rarely. This medication can affect kidney and liver function, necessitating regular blood tests and liver function tests. Elderly patients or those with chronic conditions may have an increased risk of pneumonia, thus care should be taken. When taking this medication with other drugs, the therapeutic effects may change, so inform healthcare providers about currently used medications. Women who are pregnant or breastfeeding should only use this medication when absolutely necessary, as its safety has not been sufficiently established. The safety of this medication in children has not been adequately confirmed, so it should be used with caution. While special overdose symptoms are rare, emergency measures such as vomiting or gastric lavage may be necessary. This medication should be kept out of reach of children and not transferred to other containers.

Serious side effects

• Shock
• anaphylactic shock
• hives
• angioedema
• rash
• fever
• bronchospasm
• hypotension
• chest pain
• leukopenia

Mild side effects

Increased serum creatinine levels, transient and reversible liver function impairment (increased AST, ALT, γ-GTP, ALP levels), bradycardia, atrioventricular block, tachycardia, vasculitis, constipation, nausea, vomiting, abdominal distension, abdominal pain, loss of appetite, diarrhea, dizziness, drowsiness, headache, heavy-headedness, insomnia, agitation, anxiety, mental confusion, depression, hallucination, blurred vision, involuntary movement disorders, gynecomastia, excessive lactation, erectile dysfunction, reduced libido, joint pain.

This medication is sensitive to light, so it should be stored in a container that does not allow light to enter. Additionally, it should be kept at a temperature between 1 and 30 degrees Celsius for safe use.

Appearance

Off-white to yellowish round film-coated tablet

Package unit

For domestic use - 30 tablets/bottle, For domestic use - 100 tablets/bottle