Diacerein M Capsule (Diacerein)

Adult dose

Adults: Administer diacerein 50∼100mg orally once or twice daily after meals, in divided doses. Adjust the dose as appropriate according to symptoms. For patients with a history of loose stools or diarrhea, an initial dose of 50mg once daily for the first 2-4 weeks is recommended, followed by 50mg twice daily.

This medication should not be used in patients with inflammatory bowel disease. For instance, patients with ulcerative colitis or Crohn's disease may experience worsening symptoms with this medication. Patients with intestinal obstruction syndrome should also avoid using this medication as it can be dangerous. It is advisable not to use this medication if the cause of abdominal pain is unclear. Patients who have allergic reactions to this medication or its components, particularly Rhein class drugs, should avoid taking it. Those with liver diseases or a history of liver problems should refrain from using this medication. Children under 15 years of age should not use this medication, nor should patients with lactose intolerance or genetic lactose breakdown disorders. Patients with a history of small intestine or colon disease should use this medication cautiously, and pregnant or breastfeeding women should consult their physician before use. Elderly patients over 65 years of age should reduce the dosage of this medication and follow a physician's direction for long-term use. This medication may affect the digestive system, leading to symptoms such as diarrhea, loose stools, and abdominal pain, and serious problems like gastrointestinal bleeding, ulcers, or perforations may occur with prolonged use. Severe diarrhea may lead to dehydration and electrolyte imbalance, thus caution is needed. Allergic reactions such as itching, rash, or eczema may appear on the skin, and rare liver function abnormalities may also occur, necessitating regular monitoring of liver health. This medication may interact with other drugs, so it should be taken at least 2 hours apart from antacids that contain calcium, magnesium, or aluminum. Additionally, taking it with diuretics may enhance diuretic action, increasing the risk of dehydration or hypokalemia, requiring caution. When taken with cardiac glycosides, the risk of arrhythmias may increase, thus it should be used under medical supervision. It is advisable to avoid use during pregnancy as it may affect fetal bone formation, and breastfeeding women are also recommended not to take the medication as it may partially transmit through breast milk. In cases of overdose, severe diarrhea may occur, necessitating appropriate treatment such as electrolyte supplementation.

Diarrhea, loose stools, abdominal pain, gastrointestinal disorders (bleeding, ulcers, and perforation), pigmentation of the rectal mucosa, itching, rash, eczema, elevated liver enzymes in serum

This medication should be stored in a tightly closed container to prevent air or moisture from entering and should be kept at room temperature between 1 to 30 degrees. Proper storage will help maintain the drug's effectiveness for a long time.

Appearance

Opaque hard capsules with a yellow upper part and a white lower part containing yellow crystalline powder

Package unit

30 capsules/bottle - 30 capsules/bottle, 500 capsules/bottle - 500 capsules/bottle