Hyaluron Plus Injection (Sodium Hyaluronate)

Adult dosage

Typically, for adults, 1 vial is administered once a week for 3 consecutive weeks into the knee joint space or shoulder joint (shoulder joint space, subacromial bursa, or biceps tendon sheath), but the frequency of administration should be adjusted according to symptoms.

This medication should not be used in individuals with a history of allergic reactions to its ingredients. Patients with a history of allergies to other medications or with liver function problems, or a history of liver disease should use it with caution. As this medication is administered directly into the joint, it should be used carefully if there are skin diseases or infections at the injection site. Severe allergic reactions such as shock may occur during use; if symptoms appear, administration should be stopped immediately and appropriate treatment received. Signs of hypersensitivity such as swelling around the face or eyes, rash, hives, or itching may occur. If these symptoms appear, discontinue use and seek medical attention. Temporary pain, swelling, redness, heat, or severe pressure at the site of injection may occur, so caution is required if these symptoms occur. Occasionally, symptoms such as nausea, vomiting, or fever have also been reported, so any abnormal symptoms should be reported. If inflammation in the joint is severe, this medication may exacerbate the inflammation, so it is advisable to administer it after the inflammation has subsided. After administration, care should be taken to stabilize the joint and avoid overexertion. If this medication leaks out of the joint space, pain may occur, so it must be administered precisely within the joint space. Maintain aseptic conditions during injection, and it should only be administered to the knee joint or shoulder joint; intravenous injection is absolutely prohibited. It is preferable to use a syringe needle of approximately 22-23 gauge. Care should be taken as certain disinfectants may cause the medication to precipitate. Women who are pregnant or may become pregnant should only use it with caution when the benefits outweigh the risks, and it is advisable to avoid administration while breastfeeding. Safety has not been established in children, so it should be used cautiously only when necessary. Elderly patients may have decreased bodily functions, so special care is required during administration.

Serious side effects

• Hives
• swelling (facial, eyelid, etc.)
• symptoms of shock

Mild side effects

• Facial swelling
• facial redness
• rash
• itching
• pain
• swelling
• edema
• redness
• heat
• local severe pressure

This medication should be stored in a sealed container to prevent air or moisture from entering. It is best to maintain storage temperatures between 1 degree and 30 degrees Celsius. This helps preserve the medication's efficacy and safety for a long time.

Appearance

A colorless, transparent, viscous liquid contained in a glass or plastic vial sealed with rubber stoppers at both ends (part of a prefilled syringe system)

Package unit

2 milliliters / Pre-filled syringe [2ml x 1 vial, 2ml x 3 vials]