Simvastatin/Ezetimibe 10/20 mg

Adult dose

This medication is administered once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10mg to 10/40mg per day, and the generally recommended starting dose is 10/20mg per day. Patients who require less reduction of LDL cholesterol may start with 10/10mg per day. The recommended dosage for patients with homozygous familial hypercholesterolemia is 10/40mg per day, administered once daily in the evening.

This medication is primarily used to lower blood cholesterol levels to reduce the risk of cardiovascular diseases. However, when taking this medication, muscle-related adverse effects such as muscle pain or weakness may occur, so caution is advised. Especially when taking high doses or when combined with certain medications, the risk of muscle damage may increase, so consultation with a doctor is necessary. This medication can affect liver function; therefore, it should not be taken by patients with liver diseases or abnormal liver function tests. Women who are pregnant or breastfeeding should not take this medication, and women of childbearing age should check for pregnancy possibilities and use it cautiously. Additionally, when combined with specific medications such as certain antifungal drugs, antibiotics, and antiviral agents that interfere with the metabolism of this medication in the liver, the risk of side effects can increase. If sudden muscle pain, muscle weakness, or changes in urine color occur while taking this medication, it is essential to inform healthcare professionals immediately. Elderly patients or those with impaired renal function need to be particularly cautious, and regular blood tests to check liver function and muscle enzyme levels are recommended. This medication may increase blood glucose levels in some patients, so careful management of blood glucose is necessary for those at risk of diabetes. During treatment, it is crucial to inform healthcare professionals about the use of this medication when starting any new medications, and to avoid certain foods such as grapefruit juice. In case of overdose, there are no specific antidotes, so treatment will be symptom-based. This medication is only used restrictively in children and adolescents, as safety and efficacy have not been adequately established. Therefore, strict adherence to physician instructions is essential while taking this medication, and immediate consultation is advised if any suspected adverse effects occur.

Serious side effects

Myopathy/rhabdomyolysis (severe muscle pain, weakness, elevation of creatine kinase over 10 times), angioedema, rash, pancreatitis, cholelithiasis, cholecystitis, anaphylaxis, urticaria, severe swelling (edema), chest tightness, difficulty breathing, severe skin reactions (rash, blisters, skin peeling, mucosal pain in mouth/eyes), respiratory problems (asthma attacks, cough accompanied by fever), liver abnormalities (jaundice, yellowing of skin or eyes)

Mild side effects

Headache, diarrhea, influenza-like symptoms, upper respiratory tract infections, muscle pain, limb pain, fatigue, nausea, abdominal pain, constipation, epigastric discomfort, vomiting, chest pain, chest discomfort, sensory loss, cough, edema, thirst, facial swelling, fainting, insomnia, gastritis, atrophic gastritis, dyspepsia, mucus stools, irritable bowel syndrome, sore throat, hematuria, itching, weight loss, malaise, increased serum creatine phosphokinase (CPK), nocturia, cataract, abdominal pain,

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is essential to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. Following these guidelines helps maintain the medication's effectiveness and safety for a longer duration.

Appearance

White to off-white, bilaterally convex rectangular tablets

Package unit

PTP - 30 tablets/PTP[(10 tablets/PTP*3)]