Simvastatin/Ezetimibe Tablets 10/10 mg

Adult dose

This medication is administered once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10 mg to 10/40 mg per day, with a generally recommended starting dose of 10/20 mg per day. For patients with less need for LDL cholesterol reduction, treatment may start at 10/10 mg per day. After starting therapy or after adjusting the dose, blood lipid levels should be checked at an interval of at least 4 weeks.

This medication helps to lower blood cholesterol levels. However, it is necessary to be cautious as it may cause muscle problems when taking this medication. Especially if muscle pain or weakness occurs, it should be reported to a doctor immediately. This medication can affect liver function, so it should not be taken if there is liver disease or elevated liver function tests. Women who are pregnant or breastfeeding should not use this medication. Taking it alongside certain medications that interact can increase the risk of muscle damage, so it must be discussed with a doctor. Caution is also needed for elderly patients and those with kidney disease. Additionally, regular liver function and muscle-related tests are recommended during treatment with this medication. If unexplained muscle pain, tenderness, or weakness occurs while taking this medication, treatment should be stopped immediately, and medical attention should be sought. It is essential to inform healthcare providers when starting a new medication while on this medication. In case of overdose, there is no specific antidote, and appropriate treatment should be sought at the hospital immediately.

Serious side effects

Hypersensitivity reactions including urticaria, angioedema, and rash, pancreatitis, cholelithiasis, cholecystitis, angioedema, erythema multiforme-like syndrome, polymyalgia rheumatica, dermatomyositis, vasculitis, purpura, thrombocytopenia, leukopenia, hemolytic anemia, positive antinuclear antibodies, increased erythrocyte sedimentation rate, eosinophilia, arthritis, arthralgia, photosensitivity, fever, chills, flushing, malaise, dyspnea, toxic epidermal necrolysis (Lyell syndrome), skin nodules

Mild side effects

Headache, diarrhea, influenza, upper respiratory infection, myalgia, limb pain, weakness, abdominal pain, constipation, dyspepsia, nausea, pruritus, rash, increased serum creatine phosphokinase (CPK), weight loss, thirst, facial swelling, syncope, sensory abnormalities, insomnia, gastritis, atrophic gastritis, mucus stool, irritable bowel syndrome, sore throat, nocturia, hematuria, alopecia, flatulence, chest pain, discomfort in the chest, sensory loss, cough, fatigue, dizziness

This medication should be stored in a tightly closed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius to preserve the drug's efficacy and safety for a long time.

Appearance

White to pale yellow, double convex rectangular tablets

Package unit

30 tablets/PTP[(10 tablets/PTPX3)]