NTHIHAL Plus Injection (Sodium Hyaluronate)

Adult administration

Usually, for adults, 1 vial is administered intra-articularly once a week for 3 consecutive weeks, but the frequency of administration should be adjusted appropriately based on symptoms.

This medicine should not be used by patients who have previously experienced allergic reactions to its components. Additionally, patients with a history of allergy to other medications, liver dysfunction, or a past history of liver disease should be especially cautious when using this medicine. As this medicine is injected directly into the joint, it should be administered carefully if there are skin conditions or infections at the injection site. Severe allergic reactions such as shock may occur rarely during the use of this medication; therefore, the patient's condition should be closely monitored during administration, and if abnormal symptoms occur, administration should be stopped immediately and appropriate treatment should be received. Also, if swelling, redness, itching, or rash occurs on the face or eyelids, administration should be stopped, and medical consultation should be sought. Temporary pain, swelling, redness, warmth, and pressure may occur at the injection site, as well as common side effects such as nausea, vomiting, and fever. For joints with severe inflammation, it is advisable to reduce inflammation before administering this drug, and stabilizing the injection site after administration helps in pain relief. If this drug leaks out of the joint, it may cause pain, so it is crucial to inject it accurately into the joint. Aseptic conditions must be maintained thoroughly during administration, and if symptoms do not improve, administration should be repeated only up to three times and then discontinued. If there is an accumulation of fluid in the joint, it may be necessary to remove the fluid before injection. This medicine should not be administered intravenously or used for ophthalmic purposes, and a needle gauge of 22-23 is appropriate. Furthermore, caution should be taken as it may react with certain disinfectants and form precipitates. Women who are pregnant or may become pregnant should carefully weigh the benefits and risks when using this medicine, and it is advisable to avoid administration during breastfeeding. Safety for children has not been established, so it should only be used cautiously when absolutely necessary. Elderly patients may have reduced bodily functions, so special caution should be taken when using this medication.

Serious side effects

Hives, swelling (such as facial and eyelid swelling), symptoms of shock.

Mild side effects

• Facial flushing
• itching
• pain
• swelling
• redness
• warmth
• severe local pressure
• nausea
• vomiting
• fever

This medicine should be stored in a sealed container to prevent exposure to air and should be kept at room temperature between 1 and 30 degrees Celsius. Storing it this way can help maintain the effectiveness of the drug for a longer period.

Appearance

A colorless, transparent, viscous liquid contained in a glass vial or plastic vial (pre-filled syringe) with rubber stoppers on both ends.

Package unit

2.0mL/vial X 3