Linagliptin/Metformin Duo Tablet 2.5/1000mg

Adult dose

This medication is administered twice daily with meals. 1. For those with no experience using metformin, the initial dosage is 2.5/500 mg, taken twice daily, which can be increased to 2.5/1000 mg, taken twice daily. 2. If blood sugar cannot be controlled with metformin monotherapy, take linagliptin 2.5 mg twice daily and the previously prescribed dosage of metformin. 3. For patients converting from a combination of linagliptin and metformin, begin with their existing doses of both.

This medication may cause rare but serious side effects such as lactic acidosis due to one of its active ingredients, metformin hydrochloride. The risk of lactic acidosis is higher in conditions of renal impairment, acute infection, dehydration, or severe trauma; therefore, this medication should not be used in those situations. Additionally, individuals who are allergic to any of the components included in this medication, have type 1 diabetes, diabetic ketoacidosis, severe renal impairment, acute alcohol intoxication, are pregnant, or nursing should not take this medication. When this medication is used in conjunction with sulfonylureas or insulin, there may be an increased risk of hypoglycemia, so blood glucose levels should be carefully monitored, and adjustments to the doses of other medications may be necessary. Elderly patients with decreased kidney function or those taking medications that may impact kidney function should have regular kidney function tests performed before and during treatment with this medication. Skin reactions such as acute pancreatitis or similar dermatitis may occur. If persistent and severe abdominal pain or skin blisters develop, immediate medical attention should be sought. This medication may lower vitamin B12 levels, so in cases of prolonged use, blood tests should be done to check vitamin B12 status, and supplementation should be considered if needed. Women who are pregnant or planning to become pregnant should avoid using this medication, and it is also advisable for nursing women not to take this medication. This medication can interact with other drugs, especially those that affect renal function or blood glucose levels, so it is important to consult a doctor when taking such medications together. Overdosage can lead to serious conditions like lactic acidosis, and immediate hospital treatment should be sought; typically, hemodialysis may be necessary. Lastly, the safety of this medication in children has not been established, and there are no studies on its effects on driving or operating machinery, so caution is advised. It is important to adhere to the precautions mentioned above during the use of this medication and to consult a healthcare provider at once if any unusual symptoms arise.

Serious side effects

Urticaria, angioedema, lactic acidosis, acute pancreatitis, similar dermatitis, chest tightness, difficulty breathing, dyspnea, abnormal liver function (abnormal liver function tests, hepatitis, biliary obstruction, potential jaundice), sudden and severe headache, seizures, confusion, visual disturbances, paralysis, severe swelling, increased blood pressure, acute renal injury, acute cholangitis, acute cholecystitis, cholangitis, acute pyelonephritis, pneumonia, pulmonary embolism, heart failure, angina

Mild side effects

• Nasopharyngitis
• hypersensitivity
• hypoglycemia
• taste disturbance
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is advisable to store it at room temperature between 1°C and 30°C to maintain the drug's effectiveness over time.

Appearance

Bright pink, convex, oval film-coated tablets on both sides

Package unit

60 tablets (10 tablets/PTP packaging x 6)