Niron Injection (Sodium Hyaluronate)

Adult dosage

As sodium hyaluronate, administer 25 mg once a week for 5 consecutive weeks into the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa, or biceps tendon sheath). Adjust the number of administrations appropriately depending on the symptoms.

This medicine should not be administered to certain patients. First, patients who have had allergic reactions to this medicine or any of its ingredients should not use it. Second, it should not be administered to areas with skin diseases or infections. Third, patients with liver dysfunction or a history of liver disease should be cautious as this medicine may increase liver enzyme levels. Fourth, patients allergic to avian proteins should not use this medicine. Various side effects may occur when using this medicine. The most serious side effect may be shock reactions, so the patient's condition should be carefully monitored after administration. Additionally, allergic reactions such as edema, redness, rash, urticaria, or itching may occur around the face or eyes, and if these symptoms appear, the administration should be immediately discontinued and treated. The injection site may experience temporary pain, swelling, redness, warmth, severe pressure sensation, or bruising. Rarely, symptoms like nausea, vomiting, fever, or headache may also occur. Injecting this medicine into inflamed joints may aggravate the inflammation, so it is advisable to use it after the inflammation has subsided. After administration, it is best to stabilize the joint area and avoid excessive movement. If the injection solution leaks outside the joint, pain may occur, so it must be injected precisely into the joint. Patients with rheumatoid arthritis or gouty arthritis should be cautious as inflammation may temporarily worsen. Also, within 48 hours post-injection, intense exercises such as jogging or tennis, or long-duration weight-bearing exercises should be avoided. This medicine's safety and effectiveness have not been verified when used with other intra-articular medications, so it is advisable not to combine it with other intra-articular injectables. Women who are pregnant or may become pregnant should use this medicine cautiously as its safety has not been sufficiently demonstrated, only when the therapeutic benefits outweigh the risks. Additionally, as this medicine can be transmitted through breast milk, breastfeeding during administration is not recommended. Its safety has not been verified in children, so it should only be administered cautiously when necessary. Elderly patients may have decreased bodily functions, so extra caution should be exercised during use. It is essential to administer this injection in a sterile condition, and if symptoms do not improve, administration may continue for a maximum of five times. If there is fluid accumulation in the joint, it is better to remove it before injection. This medicine is absolutely contraindicated for intravenous injection and is also not suitable for ophthalmic use. Due to its high viscosity, a syringe with a suitable size needle should be used, and the ampoule should be shaken to ensure proper mixing of the injection solution. Care should be taken not to let foreign substances enter when opening the ampoule, and caution should be exercised as mixing with antiseptics may cause precipitation. As a single-use product, it should be used immediately after opening, and any remaining medicine should be discarded. Administering a local anesthetic before injecting this medicine may aid in alleviating patient pain.

Serious side effects

• Urticaria
• edema (facial, eyelid, etc.)
• shock

Mild side effects

• Facial flushing
• itching
• pain
• swelling
• edema
• redness
• warmth
• severe localized pressure
• petechiae
• nausea

This medicine should be stored in a sealed container to prevent air or moisture from entering. Additionally, the medicine should be kept away from excessively hot or cold locations and stored at a normal room temperature between 1 degree and 30 degrees Celsius.

Appearance

A brown ampoule filled with a colorless, transparent, viscous solution, or a glass vial capped with rubber stoppers at both ends (part of a prefilled syringe system).

Package unit

2.5 milliliters × 10, 50, 100 vials