Nizagreen Capsule 150 mg (Nizatidine)

Adult dose

1. Treatment of active gastric and duodenal ulcers Adults: Administer 300mg of nizatidine once daily at bedtime or 150mg twice daily, orally in the morning and evening. Most ulcers heal within 4 weeks, but treatment may be continued for up to 8 weeks if necessary. In cases of active gastric ulcer, malignancy must be ruled out before treatment. 2. Prevention of duodenal ulcer recurrence Adults: After healing of a duodenal ulcer, administer 150mg orally once daily at bedtime. Treatment may be continued for up to 1 year; results of longer-term treatment are not known. 3. Gastroesophageal reflux disease Adults: Administer 150mg orally twice daily, in the morning and evening. Treatment may be continued for up to 12 weeks. 4. Improvement of gastric mucosal lesions Adults: Administer 150mg orally twice daily, in the morning and evening, for 2 weeks. 5. Dose adjustment for patients with severe renal impairment The dose for patients with renal impairment should be reduced and adjusted as follows. Active duodenal ulcer, gastroesophageal reflux disease (GERD), benign gastric ulcer: Creatinine clearance 20~50 ml/min: 150mg daily Creatinine clearance < 20 ml/min: 150mg every other day Maintenance therapy: Creatinine clearance 20~50 ml/min: 150mg every other day Creatinine clearance < 20 ml/min: 150mg every 3 days Some elderly patients may have a creatinine clearance below 50mL/min; based on pharmacokinetic data in patients with renal impairment, the dose should also be reduced according to renal function in these patients. The clinical effects of this dose reduction in patients with renal impairment have not been evaluated.

This medication is an H2 receptor antagonist used to suppress gastric acid secretion. Patients with hypersensitivity to this drug or those who have experienced allergic reactions to H2 receptor antagonists should not use it. Patients with a history of drug allergies should use this drug with caution, especially those with impaired liver or kidney function, who may need dose adjustments or extended dosing intervals. During use, various side effects such as skin rashes, itching, shortness of breath, blood abnormalities, digestive disorders, liver dysfunction, confusion, headaches, dizziness, heart palpitations, gynecomastia, sweating, and skin rashes may occur, and if any of these symptoms appear, immediate discontinuation of the drug and consultation with a healthcare professional is necessary. This drug can mask gastric cancer symptoms, so it should only be used after confirming malignancy, and dose adjustments are needed in patients with decreased kidney function. It is important to regularly conduct blood tests and liver and kidney function tests during treatment to monitor for abnormalities. This drug has a low potential for interactions with several medications; however, caution is advised when used concurrently with high doses of aspirin, as it may increase serum salicylate levels. Women who are pregnant or may become pregnant and breastfeeding should use this drug cautiously only if necessary, and safety in children has not been established. Elderly patients are at a higher risk for decreased kidney function, and kidney function tests should be performed before administration and monitored during use. In case of overdose, symptoms such as vomiting, diarrhea may occur, and activated charcoal administration or gastric lavage may be necessary. This drug has not shown evidence of carcinogenicity even with long-term high-dose use; however, caution is advised as it may affect liver function.

• Rash
• itching
• bronchial asthma
• laryngeal edema
• anaphylactic symptoms
• anemia
• leukopenia
• neutrophilia
• thrombocytopenic purpura
• constipation

This drug is sensitive to light and should be stored in a container that blocks light. Additionally, the drug should be stored at a temperature between 1 to 30 degrees Celsius. Storing it this way can help maintain its effectiveness and safety.

Appearance

Hard gelatin capsule with yellow upper and lower parts filled with white to off-white crystalline contents

Package unit

30 capsules/bottle, 300 capsules/bottle