Ticatu Tablet 90 mg (Ticagrelor)

Adult dose

ㆍAcute coronary syndrome: Administer a 180mg loading dose, followed by 90mg twice daily. Treatment for 12 months is recommended unless discontinuation of this medicine is clinically necessary. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. ㆍPatients with a history of myocardial infarction (occurring at least 1 year previously) who are at high risk of atherothrombotic cardiovascular events: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. - Patients who took 90mg of this medicine or another ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel) during the first year after myocardial infarction may continue treatment with 60mg of this medicine. - Treatment with this medicine may also be initiated in patients within 2 years after myocardial infarction or within 1 year after discontinuation of a previous ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel). - The safety and efficacy of this medicine were evaluated at 3 years of follow-up. ㆍPatients with type 2 diabetes who have undergone percutaneous coronary intervention (PCI) for coronary artery disease: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. - Refer to the dosage and administration for acute coronary syndrome patients. - Data on the safety and efficacy of this medicine for treatment longer than 3 years are limited. ㆍPatients with acute ischemic stroke or high-risk transient ischemic attack: Administer a 180mg loading dose, followed by 90mg twice daily for 30 days. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 100mg), unless specifically contraindicated. An initial aspirin loading dose (300-325mg) is recommended for patients with acute ischemic stroke or high-risk transient ischemic attack. This medicine is administered orally and may be taken with or without food. ㆍFor patients who have difficulty swallowing tablets, crush this medicine into a fine powder, disperse it in half a glass of water, and drink the mixture immediately. Rinse the glass with another half glass of water and drink it. This mixture may also be administered through a nasogastric tube (CH8 or larger); it is important to flush the tube with water after administration. ㆍWhen switching from another antiplatelet agent to this medicine, start this medicine 24 hours after the last dose of the previous medicine. ㆍIf a dose is missed, take only 1 tablet (the next scheduled dose) at the next scheduled dosing time. Patients with renal impairment No dose adjustment is required in patients with renal impairment. Patients with hepatic impairment No dose adjustment is required in patients with mild hepatic impairment. This medicine has not been studied in patients with severe hepatic impairment, and experience in patients with moderate hepatic impairment is limited.

Child dose

The safety and efficacy in pediatric patients under 18 years of age have not been established (see “Other”).

This medication helps maintain blood flow by preventing platelets in the blood from clumping together to form clots. During the use of this medication, there may be an increased risk of bleeding, so patients with bleeding or a history of intracranial hemorrhage should not use this medication. Patients scheduled for surgery should stop taking this medication at least 5 days prior to the surgery and consult with their doctors to reduce the risk of bleeding during the surgery. Patients at high risk of bleeding or those taking other medications that can cause bleeding should use this medication with caution. This medication can cause bradycardia, so patients with heart rhythm issues should be cautious. Patients with asthma or chronic obstructive pulmonary disease should be particularly careful as symptoms of dyspnea may occur; if symptoms are severe, they should consult a doctor. Women who are pregnant or breastfeeding should avoid using this medication or decide after consulting a doctor. It is not recommended for children and adolescents under 18 years of age as safety and efficacy have not been established. Elderly patients (75 years and older) can use this medication without special dosage adjustments, but regular kidney function tests are recommended. In case of overdose, there may be an increase in the risk of bleeding, and there is currently no antidote for this medication, so immediate medical attention is necessary. This medication may interact with other medications, so patients should inform their doctors or pharmacists of any medications they are taking. Caution is needed when driving or operating machinery as dizziness or confusion may occur.

Hemorrhage, dyspnea, hyperuricemia, gout, confusion, dizziness, syncope, headache, intracranial hemorrhage, ocular hemorrhage, vertigo, ear hemorrhage, hypotension, respiratory tract hemorrhage, gastrointestinal hemorrhage, diarrhea, nausea, dyspepsia, constipation, retroperitoneal hemorrhage, subcutaneous or skin hemorrhage, rash, itching, muscle hemorrhage, urinary tract hemorrhage, reproductive system hemorrhage, increased blood creatinine, post-procedural hemorrhage, traumatic hemorrhage, thrombotic thrombocytopenic purpura, bradyarrhythmia, atrioventricular block, angioedema, Cheyne-Stokes respiration, central sleep apnea, chest pain, pulmonary hemorrhage, pharyngitis, upper respiratory tract infection, asthma, pleural effusion, bronchitis, pneumothorax, pneumonia, pulmonary edema, weakness, anaphylactic shock, epistaxis, hemoptysis, hematoma, cerebral hemorrhage, spinal stenosis, dementia, migraine, paralysis, gait abnormalities, rectal hemorrhage, anal hemorrhage, appendicitis, tendon disease, bursitis, diabetes, hyperkalemia, hyperglycemia, thirst, worsening of diabetes, hepatitis, snoring, aneurysm, heart failure, cardiac rhythm disorder, palpitations, ventricular tachycardia, arrhythmia, ventricular fibrillation, cardiac arrest, ventricular fibrillation, urinary tract infection, kidney stones, cerebral ischemia, venous stenosis, cerebral infarction, arterial stenosis, angina pectoris, coronary artery thrombosis, myocardial ischemia, anemia, vestibular disorder, malignant neoplasm of the male genital organs, chemical poisoning, post-procedural hematoma, laceration, road traffic accident, trauma, nausea, vomiting, acute renal failure, myocardial infarction, sinusitis, bronchiectasis, sleep apnea, oral edema, influenza-like illness, tuberculosis infection, hyperthermia, unspecified hernia, dyspnea, generalized edema, thrombosis, leg venous thrombophlebitis, deep vein thrombosis, cardiac thrombus, coagulation disorder, thrombocythemia, speech disorder, cerebral hypoxia, scalp tenderness, peripheral neuropathy, neck stiffness, vocal disturbances, seizure, neuropathy, neuralgia, movement disorders, tremor, paraplegia, coma, sensory loss, oral pain, gastroenteritis, belching, irritable bowel syndrome, stomatitis, ulcerative stomatitis, benign gastrointestinal neoplasm, dental disease, tongue disease, tendinopathy, osteoarthritis, chondrocalcinosis, spinal osteoarthritis, arthritis, contact dermatitis, fungal skin disease, skin disease, erythematous rash, excessive keratinization, acute urticaria, onychomycosis, hair loss, scleroderma, dermatofibroma, increased sweating, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, lipodystrophy, dehydration, increased AST, increased ALT, drowsiness, neurosis, depression, memory disorders, erectile dysfunction, anxiety, orthostatic hypotension, worsening hypertension, cyanosis, atrial fibrillation, polyuria, dysuria, urinary incontinence, nocturia, worsening of chronic renal failure, cystitis, abnormal urination, renal cyst, urinary retention, conjunctivitis, diabetic retinopathy, cataract, tinnitus, ear pain, lymphadenopathy, eosinophilia, sexual dysfunction, benign prostatic hyperplasia, ovarian cyst, amenorrhea, vaginitis, taste loss, olfactory disturbance, increased TSH, hypothyroidism, injection site reaction, injection site pain, concussion, intervertebral disc disease, non-drug allergy, deviated septum, surgical site reaction

This medication should be stored in a tightly sealed container as it may be sensitive to air or moisture. The storage temperature should be maintained at room temperature between 1 and 30 degrees Celsius to preserve its effect.

Appearance

A yellow, round, biconvex, film-coated tablet

Package unit

56 tablets/PTP [(14 tablets/PTP x 4)]