Simvastatin/Ezetimibe Tablets 10/20 mg

Adult dose

This medication is taken once daily in the evening, regardless of meals. For patients with primary hypercholesterolemia, the dosage range is 10/10 mg to 10/40 mg daily, with the generally recommended initial dosage being 10/20 mg once daily. Patients for whom a reduction in LDL cholesterol is not needed can start with 10/10 mg once daily. For patients with homozygous familial hypercholesterolemia, the recommended dosage is 10/40 mg once daily in the evening.

This drug can cause muscle-related side effects, such as myopathy and rhabdomyolysis. The risk of these increases, particularly at high doses, so patients should report muscle pain or weakness to their doctor immediately. Patients with liver dysfunction or liver disease should not use this medication. Women who are pregnant or breastfeeding should also avoid this drug and consult a doctor if planning to become pregnant. The risk of muscle side effects can increase when this drug is taken with certain other medications, so patients should consult their doctor about any other medications they are taking. Elderly patients over the age of 65, or those with hypothyroidism or decreased kidney function must use this drug with caution. Regular liver function and muscle-related tests should be conducted during treatment, and any abnormal symptoms should be reported to healthcare providers immediately. This medication should be used with caution in children and adolescents, especially not recommended in patients under 10 years of age. Since there is no specific antidote for overdose, appropriate treatment should be sought at the hospital immediately.

Serious side effects

Urticaria, angioedema, chest tightness, difficulty breathing, cold sweat, pallor, allergic reactions including angioedema and rash, severe allergic reactions, severe swelling (edema), anaphylaxis, toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, erythema multiforme, high fever accompanied by severe rash, blistering, skin peeling, pain in oral/ocular mucosa, severe skin adverse reactions, shortness of breath or difficulty breathing

Mild side effects

Headache, diarrhea, influenza, upper respiratory tract infection, myalgia, limb pain, fatigue, nausea, abdominal pain, constipation, dyspepsia, flatulence, weakness, itching, rash, increased serum creatine phosphokinase (CPK), weight loss, nocturia, hematuria, insomnia, gastritis, atrophic gastritis, mucus stools, irritable bowel syndrome, sore throat, cataract progression (lens opacity), gynecomastia, decreased libido, sexual dysfunction (including erectile dysfunction), anemia, and hypothyroidism

This medication is sensitive to air and moisture, so it should be stored in a tightly closed container. Additionally, it is important to store it at room temperature between 1°C and 30°C to maintain its effectiveness.

Appearance

White to off-white, bilaterally convex rectangular tablets

Package unit

30 tablets/PTP [10 tablets/PTP X 3]