Linagliptin/Metformin Tablets 2.5/1000 mg

Adult dose

This medication is administered twice a day with meals. 1. If there is no prior experience with Metformin treatment, the initial dosage is 2.5/500 mg twice a day, with the possibility to increase to 2.5/1000 mg twice a day, taking one tablet each time. 2. If blood sugar control is insufficient with Metformin monotherapy, Linagliptin 2.5 mg twice a day is to be combined with the existing Metformin dosage. 3.

This medication helps in blood sugar control. However, it may rarely cause a serious side effect known as lactic acidosis, so caution is warranted. You should not take this medication if you have an allergy to its ingredients or have certain conditions such as Type 1 diabetes, lactic acidosis, diabetic ketoacidosis, or diabetic pre-coma. Patients with severely impaired kidney function or significant liver dysfunction, dehydrated patients, or those with severe infections should also avoid this medication. Additionally, it is safest for patients with acute alcohol intoxication or alcoholism, malnutrition, heart failure, or pregnant or breastfeeding women to refrain from taking this medication. When taking this medicine, symptoms of hypoglycemia may occur, so it is essential to monitor blood sugar changes closely, especially when taking it together with sulfonylureas or insulin. Due to the risk of lactic acidosis, if kidney function deteriorates suddenly or if there are respiratory diseases or septicemia, stop taking the medication immediately and consult your physician. Regular kidney function tests should be conducted to ensure the safe use of this medication, and dosing should be stopped if kidney function declines. Patients with weakened heart function should regularly monitor their cardiac and renal conditions while using this medication. When undergoing radiological examinations that involve iodinated contrast agents, the use of this medication should be temporarily suspended before and after the administration of the contrast agent and kidney function should be reassessed. Patients preparing for surgery should stop taking this medication 48 hours before the surgery and resume after kidney function has recovered post-operation. If acute pancreatitis or blistering skin diseases are suspected, stop the medication and consult a physician immediately. Gastrointestinal disturbances, hypoglycemia, vitamin B12 deficiency, myalgia, skin rashes, and other side effects may occur during use, so it is important to inform medical personnel of any unusual symptoms. This medication may interact with other drugs, so be sure to inform your doctor or pharmacist about any other medications you are taking. Pregnant or breastfeeding women are advised to avoid this medication, and if you plan to become pregnant, consult with your doctor before determining a treatment approach. Elderly patients have a higher likelihood of reduced kidney function, so it is safe to start at the minimum dose along with regular kidney function tests. In the case of overdose, the medication may not be fully absorbed in the gastrointestinal tract, and there is a risk of lactic acidosis, so hospital treatment is required immediately. This medication should be stored out of reach of children and protected from moisture.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, difficulty in breathing or shortness of breath, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), severe lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, numbness

Mild side effects

Nasopharyngitis, hypersensitivity, hypoglycemia, taste disorders, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, formation of mouth ulcers, abnormal liver function tests, hepatitis, pruritus, erythema, rash, severe arthritis accompanied by disability, increased lipase, increased amylase, decreased and deficiency of vitamin B12, angioedema, increased triglycerides, decreased hemoglobin, increased serum potassium, increased serum creatinine, increased serum creatine phosphokinase activity

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container when not in use. Moreover, it is best kept at room temperature, between 1 to 30 degrees Celsius, avoiding extremes of heat or cold.

Appearance

Biconvex bright pink oval film-coated tablets

Package unit

60 tablets (10 tablets/PTP x 6)