Rinamet Tablet 2.5/500 mg

Adult dose

The dosage of this medication is determined based on the patient's condition, not exceeding 2 doses per day of linagliptin 2.5 mg and metformin 1000 mg. This medication should be taken twice a day with meals. 1. If previously not treated with metformin, the initial dosage is 2.5/500 mg twice a day, one tablet each time, and can be increased to 2.5/1000 mg twice a day, one tablet each time. 2. Linagliptin

This medication can cause serious health risks due to a rare side effect known as lactic acidosis, so it should not be used, particularly in patients with impaired kidney function or acute illnesses. Patients with allergies to the active ingredients or components of this medication, or with certain diabetic conditions such as type 1 diabetes or diabetic ketoacidosis, should also refrain from taking it. It should be avoided in patients with severely impaired kidney function, dehydration, severe infections, heart failure, liver dysfunction, acute alcohol intoxication or chronic alcoholism. Women who are pregnant or breastfeeding are also advised not to use this medication, and women planning to become pregnant should be especially cautious. When used with other blood glucose-lowering agents, there is a risk of hypoglycemia, so patients should be well informed of hypoglycemic symptoms and dosage adjustments may be necessary if needed. This medication is affected by kidney function, thus regular kidney function tests should be performed, and if kidney function declines, dosage adjustments or discontinuation may be required. Acute pancreatitis, severe arthralgia, or bullous skin diseases may occur, so if such symptoms arise, immediate consultation with medical personnel is necessary. Vitamin B12 levels may decrease, so monitoring through blood tests is essential during prolonged use. This medication can interact with several other drugs, therefore, it is crucial to inform medical staff if taking other medications, especially those that may affect kidney function. It should not be used during pregnancy or breastfeeding, and safety in children has not been established. Elderly persons should be administered carefully due to common declines in kidney function and routine monitoring of kidney function is necessary. In cases of overdose, serious side effects such as lactic acidosis may occur, so dosage should be adhered to, and if unusual symptoms arise, immediate medical attention should be sought. Store in a place out of reach of children, avoid moisture, and do not transfer to another container.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, pseudo-pemphigus, liver dysfunction (hepatitis, abnormal liver function tests), acute pancreatitis, oral ulcer formation, severe allergic reactions (urticaria, angioedema), angina, acute myocardial infarction, unstable angina, cardiac arrest, congestive heart failure, acute kidney injury, end-stage renal disease, acute cholangitis, acute cholecystitis, cholangitis, chest tightness, difficulty breathing, shortness of breath, asthma

Mild side effects

Pharyngitis, hypersensitivity, reduced and deficient vitamin B12, hypoglycemia (when combined with sulfonylureas), taste disturbances, cough, decreased appetite, diarrhea, constipation (when used with insulin), nausea, vomiting, abdominal pain, oral ulcer formation, abnormal liver function tests, hepatitis, itching, erythema, rash, severe and disabling arthralgia, increased lipase, increased amylase, angioedema, pseudo-pemphigus, musculoskeletal and connective tissue disorders, blood

This medication is sensitive to air and moisture and should be stored in a tightly closed container. The best storage temperature is between 1 to 30 degrees Celsius. This helps maintain the efficacy of the medication for a longer time.

Appearance

Bright yellow, oval film-coated tablet with a convex surface on both sides.

Package unit

60 tablets (10 tablets/PTP x 6)