Rabeprazole Sodium 20 mg Tablets

Adult dose

For gastric ulcer and duodenal ulcer: Typically, 10 mg orally once a day, with a maximum dose of 20 mg per day depending on symptoms. Administer for a maximum of 8 weeks for gastric ulcer and a maximum of 6 weeks for duodenal ulcer. For erosive or ulcerative gastroesophageal reflux disease: Administer either 10 mg or 20 mg once daily for 4 to 8 weeks. If not treated, an additional 8 weeks of 10 mg or 20 mg may be given twice a day.

This medication should not be used in patients with certain allergic reactions. For example, it should not be administered to those with hypersensitivity to this medication or its components, or to benzimidazole derivatives. Additionally, caution is needed when using this medication in patients allergic to penicillin or macrolide antibiotics, especially in combination therapy with antibiotics for the eradication of Helicobacter pylori. It should not be used by pregnant or breastfeeding women as it may affect the fetus or newborn. Patients with decreased liver function, the elderly, and those with a history of drug allergies should use this medication with caution. Allergic reactions such as skin rash or itching may occur; if such symptoms arise, stop taking the medication immediately and consult a doctor. Regular blood tests may be necessary as changes in red blood cells, white blood cells, and platelet counts can occur. Liver function abnormalities may also occur; hence, regular liver function tests are advisable. Cardiac symptoms, changes in blood pressure, headaches, and dizziness have also been reported, so attention should be given if these symptoms occur. Digestive symptoms may include diarrhea, abdominal pain, and nausea, and any abnormal symptoms should be reported to a doctor. It may affect the mental and neurological system, leading to anxiety, insomnia, drowsiness, and depression, so caution is needed. Respiratory symptoms, muscle pain, joint pain, and skin adverse reactions have also been reported, so consultation with healthcare personnel is recommended if symptoms arise. Long-term use of this medication may increase the risk of osteoporosis and fractures, hence being cautious during prolonged usage is necessary. Hypomagnesemia may rarely occur, so patients taking this medication long-term or in conjunction with certain drugs should regularly check magnesium levels. As this medication strongly suppresses gastric acid secretion, there is a slightly increased risk of gastrointestinal bacterial infections. Particularly, if diarrhea persists for a long time, consult a doctor. Caution is necessary while driving or operating machinery as drowsiness may occur. There may be interactions with other medications, so especially if taking antibiotics, anticoagulants, or antiviral drugs, it is essential to inform a doctor. This medication should not be chewed or crushed, but taken whole in tablet form, and stored out of reach of children. In case of overdose, there is no specific antidote, but appropriate treatment should be provided based on symptoms, as the medication is not easily dialyzable. Finally, long-term use of this medication may lead to vitamin B12 absorption disorders, so monitoring of this is necessary during prolonged usage.

Serious side effects

• Hives, severe swelling (edema), chest tightness, breathing difficulties → severe allergic reactions.
• Fulminant hepatitis, liver dysfunction, jaundice → liver abnormalities (jaundice).
• Severe rash, blisters, skin peeling, oral/ocular mucosal pain → severe skin abnormalities.
• Dyspnea, asthma, apneas, respiratory depression → respiratory issues.
• Severe neurological symptoms: sudden and severe headaches, lightning headaches, seizures, confusion, visual disturbances, paralysis.

Mild side effects

• Occasionally rash
• hives
• itching
• decreased red blood cells
• decreased white blood cells
• increased white blood cells
• increased eosinophils
• increased neutrophils
• decreased lymphocytes
• anemia

This medication can be sensitive to air and moisture, so it must be stored in a tightly closed container. It is important to maintain a storage temperature between 1 to 30 degrees Celsius. Proper storage will ensure the medication's effectiveness.

Appearance

Pale yellow round enteric coated tablets

Package unit

28 tablets (14 tablets / PTP*2)