Donggu Hyaluronic Acid Injection (Sodium Hyaluronate)

Adult dosage

As sodium hyaluronate, 25 mg should be administered once a week for 5 consecutive weeks into the knee joint or shoulder joint, but the number of administrations should be adjusted appropriately according to symptoms.

This medication should not be used in certain patients. Patients who have had allergic reactions to this drug or its components should not be administered this medication. Patients with skin disease or infection in the joint area should also refrain from using this drug. Caution is necessary for patients with liver function problems or a history of liver disorders. Persons allergic to avian protein should avoid this medication. When using this medication, side effects may occur, so caution is advised. Severe allergic reactions such as shock may occur, so patients should be closely monitored, and if any abnormal symptoms appear, the administration should be immediately stopped, and appropriate treatment should be provided. Swelling, redness, rash, hives, and itching may appear around the face or eyes, in which case, administration should also be stopped, and treatment is needed. Temporary pain, swelling, redness, warmth, pressure, and bruising may occur at the administration site. Symptoms such as nausea, vomiting, fever, and headache may also occur. In patients with severe inflammatory arthritis, it is advisable to reduce inflammation before administering this medication. After administration, the joint area should be stabilized, and excessive movement should be avoided. If the drug leaks outside the joint, pain may develop, so it is important to inject it precisely into the joint. Care is needed in administering this drug to patients with rheumatoid arthritis or gout, as inflammation may temporarily worsen. It is advisable not to perform vigorous exercises such as jogging or tennis, or any weight-bearing activities for long periods within 48 hours after administration. The use of this medication together with other intra-articular injectables is not recommended as its safety and efficacy have not been confirmed. Women who are pregnant or may become pregnant should use this medication with caution, and should only administer it when the benefits of treatment outweigh the risks. Additionally, as this drug may be transferred through breast milk, it is advisable to avoid breastfeeding during administration. The safety of this medication has not been established in children, so it should be used cautiously only when necessary. Elderly patients may have reduced bodily functions and should use this medication with greater caution. The injection should be performed under sterile conditions and should only be administered to the knee or shoulder joint. If symptoms do not improve, administration should be limited to a maximum of 5 times and then discontinued. It is advisable to remove any accumulated joint fluid beforehand. Intravenous administration is strictly prohibited, and this medication is not used for ophthalmic purposes. Due to its high viscosity, care must be taken when selecting the needle and using the syringe. The upper part of the ampoule may contain the injectable solution, so it should be slowly aspirated and, when cutting, wiped clean to prevent contamination. Caution should be taken as the use of disinfectants like benzalkonium chloride or chlorhexidine may cause precipitation. This medication is for single use only and should be quickly used after opening; any remaining medication should be discarded. It is recommended to first administer a local anesthetic before using this medication.

Serious side effects

Hives

Mild side effects

Swelling (facial, eyelid, etc.), facial flushing, rash, itching, pain (mainly transient pain after administration), swelling, edema, redness, warmth, severe localized pressure, petechiae, nausea, vomiting, fever, headache

This medication should be stored in a sealed container to prevent air or moisture from entering. It is advisable to maintain the storage temperature between 1 degree and 30 degrees Celsius. This helps to preserve the efficacy and safety of the medication.

Appearance

A colorless, transparent, viscous liquid filled in a glass vial sealed with a rubber cap at both ends (part of a prefilled syringe system)

Package unit

10 prefilled syringes/box (2.5 milliliters/prefilled syringe × 10), 50 prefilled syringes/box (2.5 milliliters/prefilled syringe × 50), 100 prefilled syringes/box (2.5 milliliters/prefilled syringe × 100)