Sintexpin Tablet 5 mg (Amlodipine Besilate)

Adult dose

Adults: Amlodipine 5 mg orally once daily, can be increased up to a maximum of 10 mg per day based on the patient's response. Adjust according to age and symptoms.

This medication should not be administered to certain patients. It should not be used in individuals who are allergic to this medication or similar drugs, those who are breastfeeding, patients with severe liver dysfunction, those with severe heart valve disease, and patients in a state of shock. Furthermore, it should be used with caution in patients with severe hypotension, those with very poor kidney function requiring dialysis, elderly patients, and women who are pregnant or may become pregnant. Various side effects may occur when taking this medication. The most common side effects include flushing, fatigue, swelling, palpitation, dizziness, headache, drowsiness, abdominal pain, and nausea. Rarely, very low blood pressure, vasculitis, neurological abnormal symptoms, erectile dysfunction, gynecomastia, dyspepsia, weight changes, skin rash, hair loss, and allergic reactions may occur. Cardiac-related adverse reactions have also been reported rarely, and there may be blood pressure drop or cardiac rhythm irregularities, so caution is required. Patients with heart failure and poor liver function must be more careful when using this medication, and after discontinuation, blood pressure may drop gradually, so caution is needed when used with other antihypertensives. This medication is unlikely to significantly impair driving or machine operation abilities. Interactions may occur when taken with other medications, particularly when combined with specific antibiotics, antihypertensives, analgesics, grapefruit juice, etc.; consultation with a physician or pharmacist is advised. The safety of this medication during pregnancy or lactation has not been established, so it should be avoided if possible or used only when necessary, and breastfeeding should be discontinued. In children, some doses have shown hypotensive effects, but the safety and efficacy in children under 6 years of age are not known. In case of overdose, severe hypotension and heart problems may occur; immediate medical treatment is necessary. In emergency situations, continuous monitoring of blood pressure and heart condition and appropriate action should be taken. This medication is known to pose no risk of carcinogenicity or genetic mutations and is considered safe for long-term use.

Serious side effects

• Hives
• severe swelling (edema)
• difficulty breathing
• yellowing of the skin or eyes (jaundice)
• extreme lethargy
• toxic epidermal necrolysis
• angioedema
• erythema multiforme
• hepatitis
• jaundice

Mild side effects

• Flushing
• fatigue
• swelling
• palpitation
• dizziness
• headache
• drowsiness
• abdominal pain
• nausea
• weakness

This medication is sensitive to air and moisture; therefore, it should be stored in a sealed container. It is recommended to maintain storage temperatures between 1 to 30 degrees Celsius at room temperature.

Appearance

White octagonal tablet

Package unit

30 tablets/bottle, 300 tablets/bottle