Donepezil Hydrochloride Tablets 23 mg

Adult dose

This medication is taken once daily, right before bedtime, and can be administered regardless of meals. The initial recommended dose of Donepezil Hydrochloride is 5 mg once daily. After administering 5 mg for 4 to 6 weeks and evaluating clinical response, it may be increased up to 10 mg. If increasing to 10 mg daily, caution regarding gastrointestinal adverse reactions should be observed. The patient should take 10 mg once daily for a minimum of 3 months.

This medication should not be used by patients who are hypersensitive to specific ingredients, pregnant or nursing women, or patients with genetic lactose metabolism disorders. Patients with heart disease or cardiac conduction disorders should be cautious as this medication may induce heart problems such as bradycardia or arrhythmia. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should use this medication carefully, as it may stimulate gastric acid secretion and exacerbate ulcer symptoms. Patients with a history of asthma or obstructive pulmonary disease should be cautious, as broncho-constriction or increased mucus secretion could worsen their symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should administer this medication cautiously, as it could worsen their symptoms. Severe side effects such as fainting, heart block, gastrointestinal bleeding, liver dysfunction, cerebrovascular disorders, extrapyramidal disorders, neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute renal failure, and sudden death may occur. If any unusual symptoms arise, consult a physician immediately. Additionally, various side effects such as nausea, vomiting, diarrhea, loss of appetite, dizziness, insomnia, hallucinations, anxiety, headaches, etc., have been reported, so it is good to monitor any symptoms during the intake. This medication is intended for the treatment of Alzheimer's disease, and if there is no therapeutic effect or if severe side effects occur, the administration may be stopped. Patients with heart disease or electrolyte abnormalities, those with a history of peptic ulcers, or those using neuromuscular blockers need to take special caution during administration, and should regularly undergo ECG tests and symptom monitoring as directed by their physician. Pregnant or breastfeeding women should avoid using this medication unless absolutely necessary, and should consult a professional before use. This drug is metabolized by CYP3A4 and CYP2D6 enzymes; thus, its effectiveness may change when combined with certain medications. Therefore, any other medications being taken should be disclosed. In case of overdose, serious symptoms like nausea, vomiting, bradycardia, and respiratory depression may occur, and immediate medical attention is required. This medication should be stored out of reach of children and should not be transferred to a different container for safety. During intake, be cautious when driving or operating machinery, as dizziness or drowsiness may occur.

Serious side effects

• Fainting
• bradycardia
• heart block
• QT interval prolongation
• myocardial infarction
• heart failure
• peptic ulcers
• perforation of the duodenal wall
• gastrointestinal bleeding
• hepatitis

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headaches
• fatigue
• lethargy
• dizziness
• drowsiness
• insomnia

This medication should be stored in a tightly sealed container to prevent air exposure, and should be kept at room temperature between 1 °C and 30 °C. Storing it this way helps maintain its effectiveness and prevent deterioration.

Appearance

Brownish-red, round, biconvex film-coated tablet

Package unit

30 tablets/bottle