Ranicose 150 mg (Ranitidine Hydrochloride)

Adult dose

As ranitidine, take 150 mg orally twice a day, in the morning and at bedtime. 1) For gastric and duodenal ulcers: Take 150 mg orally twice daily or 300 mg once a day at bedtime. Particularly in patients with duodenal ulcers, 300 mg may be taken twice a day in the morning and before sleep. 2) For gastroesophageal reflux disease: Take 150 mg orally twice daily for 8 weeks or 300 mg once daily before bedtime.

Child dose

Children aged 8 to 18 years can be administered 150 mg once (2 mg per kg of body weight), up to twice a day.

This medication should not be used in patients who have previously shown allergic reactions to this medication’s components. It should also not be administered to patients with a rare disease called acute porphyria. For patients with impaired kidney function, the medication may remain in the body for a prolonged period, requiring dosage reduction or increased dosing intervals. Patients with decreased liver function should also use this medication cautiously. Caution is advised for patients with a history of drug allergies and for the elderly. Patients taking non-steroidal anti-inflammatory drugs, especially the elderly or those with a history of peptic ulcers, require regular examinations. This medication may mask symptoms of gastric cancer; thus, patients with gastric ulcers or those over middle age who have newly developed or changed indigestion must be assessed to confirm the absence of malignant diseases before treatment. Patients with Helicobacter pylori infections should undergo eradication therapy concurrently with treatment for gastric or duodenal ulcers. This medication may rarely cause severe allergic reactions such as anaphylactic shock; if any unusual symptoms occur, administration should be discontinued immediately and medical treatment sought. Symptoms of hypersensitivity, including hives, rash, difficulty breathing, and low blood pressure, may also occur. Rare blood abnormalities such as leukopenia and thrombocytopenia may manifest, necessitating checks if symptoms like systemic fatigue, bleeding, or fever arise. Symptoms of liver dysfunction may appear; if jaundice or abnormal liver function tests occur, use should be discontinued immediately. Gastrointestinal symptoms such as arrhythmia, constipation, nausea, and abdominal pain have been reported. Rare neurological symptoms such as dizziness, drowsiness, headaches, confusion, and insomnia may also occur. It is important to undergo regular blood tests, liver function tests, and kidney function tests. The elderly, patients with chronic lung disease, and diabetics may have an increased risk of pneumonia and should exercise caution. When experiencing dizziness or drowsiness while taking this medication, avoid driving or operating hazardous machinery. This medication may interact with other drugs, necessitating possible dosage adjustments or discontinuation of co-administered medications. Particularly when used with the anticoagulant warfarin, careful monitoring of blood coagulation times is essential. It is recommended to take this medication at least 2 hours apart from sucralfate. Women who are pregnant or may become pregnant, as well as breastfeeding women, should only use this medication when the benefits outweigh the risks. Safety in children has not been fully established, so it should be used cautiously. Older patients may have higher drug concentrations due to decreased kidney function; therefore, dosage and administration intervals need to be adjusted. This medication may cause false positive reactions in urine protein tests, thus it is advisable to use different testing methods. In case of overdose, appropriate treatment such as vomiting or gastric lavage is required; in severe cases, the medication may be removed via hemodialysis. It should be stored out of reach of children, and transferring to another container may pose a risk of accidents and degradation of quality.

Serious side effects

• Hives
• angioedema
• anaphylactic shock
• bronchospasm
• chest pain
• hypotension
• angioedema
• jaundice
• seizures
• altered consciousness

Mild side effects

Rash, fever, angioedema, hypotension, chest pain, agranulocytosis, increased serum creatinine levels, leukopenia, thrombocytopenia, bone marrow suppression, aplastic anemia, hypereosinophilia, liver dysfunction (increased AST, ALT, γ-GTP, ALP levels), bradycardia, heart block, tachycardia, vasculitis, constipation, nausea, vomiting, abdominal distension, abdominal pain, loss of appetite, diarrhea, dizziness, drowsiness, heaviness, insomnia, excitement

This medication should be stored in a sealed container to prevent air exposure and kept in a dry place at room temperature, between 1 to 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication for an extended period.

Appearance

White round film-coated tablet

Package unit

100 tablets (10 tablets/PTP*10), 300 tablets/bottle