Covalset Tablets 80/12.5 mg

Adult dose

The recommended adult dosage is 80 mg of valsartan and 12.5 mg of hydrochlorothiazide, taken once daily as one tablet with a small amount of water, irrespective of meals. The dosage of valsartan 160 mg and hydrochlorothiazide 12.5 mg applies when prescribed for blood pressure reduction. In patients with mild to moderate renal impairment, dose adjustment is not necessary. For patients with liver impairment who do not have cholestasis,

This medication may cause serious harm to the fetus if taken during pregnancy, particularly in the second and third trimesters, so it should be discontinued immediately upon confirmation of pregnancy. Patients with allergies to the ingredients of this medication or sulfonamide drugs should not use it. It should not be administered to patients with severely impaired liver or kidney function, certain liver diseases, or very poor kidney function. Patients with a history of angioedema or those who have previously experienced angioedema after taking ACE inhibitors or angiotensin II receptor antagonists should also avoid this medication. Patients with electrolyte imbalances, fluid depletion, renal or hepatic dysfunction, acute angle-closure glaucoma, cerebrovascular disease, elderly patients, and those with heart failure should use this medication cautiously. In particular, this medication can cause or worsen electrolyte abnormalities such as hypokalemia, hyponatremia, hypercalcemia, and hyperuricemia, so regular blood tests are necessary. Dizziness or drowsiness may occur during the use of this medication, so caution is advised when driving or operating machinery. Potassium supplements or potassium-containing foods should not be taken without consulting a physician, and care should be taken, especially in cases of dehydration, excessive sweating, diarrhea, or vomiting, as blood pressure may drop excessively. Additionally, this medication may interact with other blood pressure medications, diuretics, lithium preparations, NSAIDs, etc., so it is essential to discuss any other medications being taken with a physician or pharmacist. The hydrochlorothiazide component may increase sensitivity to sunlight, raising the risk of skin cancer, so limiting sun exposure and taking protective measures is important. The safety and efficacy of this medication in pediatric patients have not been established, and it can be used in elderly patients without special dose adjustment but with caution. In case of overdose, symptoms such as hypotension, arrhythmia, and electrolyte disturbances may arise, necessitating immediate medical attention and appropriate treatment. Store this medication out of reach of children, keep it away from moisture, and store it in its original container.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, symptoms of anaphylaxis, angioedema, hepatitis, renal failure, hyperkalemia, hyponatremia, shock, syncope, loss of consciousness, agranulocytosis, leukopenia, thrombocytopenia, aplastic anemia, hemolytic anemia, necrotizing vasculitis, toxic epidermal necrolysis (Stevens-Johnson syndrome), interstitial pneumonia, pulmonary edema, exacerbation of systemic lupus erythematosus, hypoglycemia, rhabdomyolysis, angioedema,

Mild side effects

• Headache
• dizziness
• nasopharyngitis
• fatigue
• back pain
• cough
• upper respiratory infection
• diarrhea
• joint pain
• abdominal pain

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It is advisable to maintain a storage temperature below 30 degrees Celsius. This will help preserve the medication's effectiveness for a longer duration.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle