Linatop Duo Tablet 2.5/850 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication is administered twice daily with meals. 1. For those not previously treated with metformin, the initial dose is one tablet of 2.5/500 mg twice a day, and it may be increased to one tablet of 2.5/1000 mg twice a day. 2. If metformin monotherapy is inadequate, take linagliptin 2.5 mg twice daily along with the existing metformin dose. 3. For patients transitioning from combination therapy with linagliptin and metformin

This medication can cause a rare but serious side effect called lactic acidosis, and should not be used in patients with poor kidney function or conditions such as severe infections, dehydration, or acute heart disease. It should also not be administered to patients who are allergic to any of its components, or to those with type 1 diabetes, diabetic ketoacidosis, or diabetic coma. Patients with weak kidney function or the elderly should regularly monitor their kidney function while using this medication, and it is strictly prohibited in cases of severely impaired kidney function. This medication may cause hypoglycemia, so caution should be exercised for symptoms of hypoglycemia when used in combination with insulin or sulfonylureas, and the dosage of these medications may need to be adjusted if necessary. Skin conditions such as acute pancreatitis or bullous pemphigoid may occur, so if abdominal pain or blistering on the skin occurs, consult a doctor immediately. Since vitamin B12 levels may decrease with long-term use, it is recommended to check vitamin B12 status through blood tests during prolonged treatment. Women who are pregnant or may become pregnant, as well as those who are breastfeeding, are advised not to use this medication, and should consult a doctor if planning to become pregnant. This medication is not recommended for children under 10 years of age and adolescents between the ages of 10 to 17 years, as its safety and efficacy have not been established in these populations. As this medication requires careful monitoring, patients should regularly see a doctor while taking it and report any adverse reactions immediately. Additionally, this medication may interact with other medications, so it is essential to inform healthcare providers of any concurrent medications and manage them carefully.

Serious side effects

• Urticaria
• angioedema
• pancreatitis
• bullous pemphigoid
• abnormal liver function tests
• hepatitis
• angina
• acute myocardial infarction
• unstable angina
• cardiac arrest

Mild side effects

• Nasopharyngitis
• hypersensitivity
• urticaria
• angioedema
• decreased and deficiency of vitamin B12
• hypoglycemia
• taste disturbance
• cough
• decreased appetite
• diarrhea

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is best to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

Bright orange oval film-coated tablet

Package unit

60 tablets (10 tablets/PTP x 6)