Linatop Duo Tablet 2.5/500 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication is administered twice daily with meals. The dosage should not exceed the maximum recommended doses of 2.5 mg of linagliptin and 1000 mg of metformin, taken twice daily. If the patient has not been treated with metformin, the initial dosage is 2.5/500 mg, one tablet twice daily; dosage may be increased to 2.5/1000 mg, one tablet twice daily. For those switching from insulin therapy with metformin, the initial dosage of this medication should be similar to the previously taken doses of linagliptin and metformin.

This medication has the potential to cause a serious adverse effect called lactic acidosis, therefore should not be administered to patients with kidney dysfunction or acute illness. Individuals who are allergic to any components of this medication or those with type 1 diabetes, pregnant or breastfeeding women should avoid its use. There is a risk of hypoglycemia, especially when used in conjunction with sulfonylureas or insulin, and dosage adjustments may be necessary in such cases. Kidney function should be monitored regularly, and the medication should be discontinued if renal function declines. Care should also be taken in patients with weak cardiac function or acute heart conditions. If undergoing radiological tests involving iodine contrast agents, the medication should be stopped for a period before and after the test, and kidney function must be assessed. Rare side effects such as acute pancreatitis and blistering skin conditions have been reported, and if continuous abdominal pain or skin blisters occur during treatment, consult a doctor immediately. This medication may cause gastrointestinal disorders, taste disturbances, vitamin B12 deficiency, etc., so routine testing may be necessary during long-term use. Women who are pregnant or planning a pregnancy should not use this medication and consult a physician, and breastfeeding should also be avoided. Older adults are at higher risk of decreased kidney function, thus dosage adjustments and regular monitoring of kidney function are necessary. This medication may interact with other drugs, so it is essential to inform the healthcare provider of any concurrently taken medications. In case of overdose, the risk of lactic acidosis increases, requiring immediate treatment at a hospital, and blood dialysis may be necessary. When storing, keep out of reach of children and avoid moisture.

Serious side effects

• Urticaria
• angioedema
• lactic acidosis
• pancreatitis
• blistering dermatitis
• abnormal liver function
• hepatitis
• acute pancreatitis
• severe allergic reactions
• severe skin reactions

Mild side effects

• Nasopharyngitis
• hypersensitivity
• angioedema
• hypoglycemia
• taste disorder
• cough
• decreased appetite
• diarrhea
• constipation
• nausea

This medication is sensitive to air and moisture, therefore, it should be stored tightly closed. It is best stored at room temperature between 1 to 30 degrees Celsius. This way, the effectiveness of the medication can be maintained for a longer period.

Appearance

Bright yellow oval film-coated tablet

Package unit

60 tablets (10 tablets/PTP × 6)