Linatop Duo Tablets 2.5/1000 mg (Linagliptin, Metformin Hydrochloride)

Adult dose

This medication is administered twice daily with meals. 1. For those not previously treated with metformin: The initial dosage is to take this medication 2.5/500 mg, twice daily, 1 tablet each time, and it can be increased to 2.5/1000 mg, twice daily, 1 tablet each time. 2. In cases where adequate blood sugar control is difficult with metformin monotherapy: Administer Linagliptin 2.5 mg twice daily and the existing metformin dosage.

This medication helps control blood sugar. However, it can cause a rare but serious side effect called lactic acidosis, so it should not be administered to patients with impaired kidney function or certain heart diseases and liver dysfunction. Patients who are allergic to the components of this medication, or those with type 1 diabetes, acute myocardial infarction, should also not use it. Additionally, women who are pregnant or breastfeeding should not take this medication. Due to the risk of hypoglycemia, caution is necessary when used in conjunction with insulin or sulfonylureas, and dosage adjustments may be required. Caution should also be exercised in elderly patients with impaired kidney function or those taking medications that may affect kidney function. In situations that can cause rapid changes in kidney function, such as acute infections, dehydration, severe trauma, or pre-and post-surgery, the use of this drug should be temporarily suspended. If iodinated contrast agents used in radiological examinations are to be administered, this medication should also be temporarily stopped before and after the examination, and renal function should be monitored. Gastrointestinal disturbances (abdominal pain, diarrhea, vomiting, etc.) may occur at the beginning of treatment, but they usually improve over time. Additionally, since a deficiency of vitamin B12 may occur, it's advisable to monitor blood vitamin B12 levels during long-term use. If symptoms of acute pancreatitis or bullous pemphigoid (blister formation on the skin) appear, discontinuation of the medication should be immediate and consultation with a physician is necessary. This medication is not recommended for children and pediatric patients under 10 years of age, and elderly patients should be administered the minimum dosage while regularly monitoring kidney function. In cases of overdose, the risk of lactic acidosis is present, requiring immediate treatment, and blood dialysis is an effective treatment method. This medication should be kept out of reach of children, stored away from moisture, and should not be transferred to another container. Lastly, alcohol consumption should be avoided as it may increase the risk of lactic acidosis, and if you are taking other medications that may interact with this medication, consult a physician or pharmacist.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, abnormal liver function (abnormal liver function tests, hepatitis), angina, acute myocardial infarction, unstable angina, congestive heart failure, cardiac arrest, cerebral infarction, acute kidney injury, end-stage renal disease, acute pyelonephritis, cholangitis, acute cholecystitis, acute cholangitis, fever, death, chest tightness, dyspnea, asthma, respiratory distress, severe edema, facial edema, elevated blood pressure, heart.

Mild side effects

Nasopharyngitis, hypersensitivity, decrease and deficiency of vitamin B12, hypoglycemia (when used with sulfonylureas), taste disorders, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, oral ulcer formation, abnormal liver function tests, hepatitis, pruritus, erythema, rash, severe joint pain accompanied by disability, rhabdomyolysis, increased lipase, increased amylase, headache, drowsiness, dizziness, sensory decrease, fatigue, chest discomfort, weakness.

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is recommended to maintain the storage temperature between 1 to 30 degrees Celsius at room temperature to preserve the efficacy and safety of the drug for a longer period.

Appearance

Bright pink oval film-coated tablets

Package unit

60 tablets (10 tablets/PTP x 6)