Doneil Tablet 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. For 4-6 weeks, the 5 mg dose should be administered, and after evaluating clinical response during this period, it may be increased to 10 mg. When increasing to 10 mg daily, attention should be paid to gastrointestinal adverse reactions. Underweight elderly women (85 years and older) should not exceed 5 mg daily, and careful monitoring is required due to the risk of adverse reactions.

Child dose

There is no experience of use in pediatric patients.

This medication contains Donepezil hydrochloride as its active ingredient and is used for alleviating the symptoms of Alzheimer's dementia. First, this medication should not be used in patients with hypersensitivity to Donepezil or similar compounds, those with specific genetic issues like lactose intolerance, and in women who are pregnant or breastfeeding. Patients with heart disease or heart conduction disorders should be cautious when using this medication, as it may cause heart problems such as bradycardia or arrhythmia. Patients taking nonsteroidal anti-inflammatory drugs or those with a history of peptic ulcers should use this medication carefully, as it can stimulate gastric acid secretion and exacerbate symptoms. Patients with asthma or obstructive pulmonary diseases should be cautious, as bronchoconstriction or increased mucus secretion may worsen their symptoms. Patients with extrapyramidal disorders, such as Parkinson's disease, should be administered this medication carefully due to the potential for symptom worsening. This medication contains the dye Yellow No. 5, so patients allergic to this component should be cautious. During the use of this medication, serious side effects including fainting, bradycardia, heart block, gastrointestinal bleeding, liver dysfunction, seizure, movement disorders, muscle tone abnormalities, acute pancreatitis, acute renal failure, etc., may occur. If any unusual symptoms appear, immediate consultation with a doctor is necessary. Additionally, various side effects such as diarrhea, nausea, vomiting, appetite loss, dizziness, insomnia, headache, myalgia, rash, etc. have been reported, and patients should inform medical staff of any symptoms that arise. This medication may affect the cardiovascular system, so patients with a history of heart disease or QT interval prolongation require regular monitoring, including an electrocardiogram. It may impact driving or machine operation, so caution is needed during the initial period of use or when changing doses. This medication can interact with other drugs, especially those affecting CYP3A4 and CYP2D6 enzymes, heart medications, anticholinergic drugs, NSAIDs, etc., so consultation with a doctor or pharmacist is essential when taking them together. Women who are pregnant or breastfeeding should not use this medication, and if necessary, they should follow the expert's instructions. Safety in children has not been established, so it should not be used in pediatric patients. In case of overdose, serious symptoms may occur including nausea, vomiting, bradycardia, hypotension, respiratory depression, and muscle weakness, requiring immediate emergency treatment. This medication should be stored out of the reach of children, and transferring it to another container is not good for maintaining quality and safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, pallor, cold sweat, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, dyspnea or difficulty breathing, asthma attack, respiratory abnormalities with cough + fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, lightning headache, seizures, altered consciousness, visual disturbances, paralysis, urination

Mild side effects

• Loss of appetite
• nausea
• vomiting
• diarrhea
• dizziness
• insomnia
• headache
• drowsiness
• fatigue
• myalgia

This medication should be stored in a sealed container to prevent air and moisture from entering, maintaining a temperature between 1 and 30 degrees Celsius to preserve its effectiveness over time.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle