Silostam Extended-Release Capsule 100 mg (Silostazol)

Adult dose

For silostazol, the usual adult dosage is 200 mg orally once daily. This medication should be taken on an empty stomach, avoiding meals.

This drug may increase heart rate, so careful observation for symptoms of angina is necessary. It should not be used in patients with bleeding or at high risk of bleeding, and patients with heart failure should avoid this medication as it may worsen their symptoms. It is also not administered to patients with a history of allergic reactions to this drug and to pregnant or potentially pregnant women, and nursing mothers. Patients taking anticoagulants, antiplatelet agents, thrombolytics, women during menstruation, patients with cardiovascular diseases, severe renal or liver dysfunction, diabetes patients, and hypertension patients should be cautious when using this medication. Possible side effects include headaches, diarrhea, palpitations, swelling of joints, and in rare cases, serious side effects such as severe bleeding, blood disorders, and interstitial pneumonia may occur. Symptoms of bleeding or early signs of blood disorders should be reported promptly during administration, and blood pressure and heart conditions should be closely monitored. This drug may cause dizziness, so caution is required when driving or operating machinery. Taking it with food may increase drug concentration and the risk of side effects, so taking it on an empty stomach is preferred, especially after a high-fat meal. This drug is metabolized in the liver, so taking it with medications that inhibit liver metabolic enzymes may increase drug concentration, requiring dosage adjustment. Additionally, when combined with antihypertensive agents or vasodilators, side effects such as increased heart rate and hypotension may occur, so caution is needed. Pregnant or nursing women should not use this medication, and children and the elderly may require dosage adjustments due to differing physiological functions. In case of overdose, severe headaches, diarrhea, hypotension, tachycardia, etc., may occur, requiring immediate medical attention.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, severe allergic reactions, cerebral hemorrhage, intracranial hemorrhage (headache, nausea, vomiting, consciousness disturbance, hemiplegia), pulmonary hemorrhage, gastrointestinal bleeding, nasal bleeding, retinal hemorrhage, hematuria, pancytopenia, agranulocytosis, thrombocytopenia, leukopenia, aplastic anemia, interstitial pneumonia (fever, cough, difficulty breathing, chest X-ray abnormalities, eosinophilia), congestive heart failure, myocardial infarction, angina, ventricular tachycardia.

Mild side effects

• Headache
• diarrhea
• palpitations
• joint swelling
• limb pain
• chest discomfort
• phototoxic reactions
• rash
• urticaria
• itching

Store this medication in a tightly sealed container to prevent exposure to air or moisture. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature to preserve the drug's efficacy and safety.

Appearance

Hard capsules with white or light yellow granules, upper and lower part white.

Package unit

500 capsules/bottle, 30 capsules/bottle