Mizartan Plus Tablet 80/12.5 mg (Telmisartan, Hydrochlorothiazide)

Adult dose

For patients whose blood pressure is not adequately controlled with Telmisartan alone, take one tablet once daily with water, regardless of meals. Before switching to this fixed-dose combination medication, it is recommended to adjust the doses of the individual components based on individual needs. If clinically appropriate, a direct switch from monotherapy to this medication may be considered. - Telmisartan/Hydrochlorothiazide combination 40/12.5 mg can be given to patients whose blood pressure is not adequately controlled with Telmisartan 40 mg. - Telmisartan/Hydrochlorothiazide combination 80/12.5 mg can be given to patients whose blood pressure is not adequately controlled with Telmisartan 80 mg. - Telmisartan/Hydrochlorothiazide combination 80/25 mg can be given to patients whose blood pressure is not controlled either with Telmisartan 80 mg and Hydrochlorothiazide 12.5 mg alone or in combination. Before starting this medication, sodium or blood volume depletion should be corrected. Patients with renal impairment Patients with mild to moderate renal impairment do not require dose adjustment. This medication should not be administered to patients with severe renal impairment (creatinine clearance <30 mL/min). Regular monitoring of kidney function is recommended. Patients with liver impairment Patients with mild to moderate liver impairment should be given this medication with caution. The daily dose should not exceed 40/12.5 mg. This medication should not be given to patients with severe liver impairment (refer to precautions on use). Thiazide diuretics require careful administration in patients with liver function disorders. Elderly population No dose adjustment is necessary. Pediatric population Safety and efficacy of this medication have not been established in children under the age of 18.

Child dose

Safety and efficacy of this medication have not been established in children under the age of 18.

This medication can pose a significant risk to the fetus, especially during the second and third trimesters of pregnancy, and should be discontinued immediately upon confirmation of pregnancy. This medication should not be administered to patients with an allergy to the active ingredients or additives, pregnant or nursing women, or patients with severe liver or kidney diseases. Elderly patients, those with elevated potassium levels, or patients with weakened liver function, valvular heart disease, or ischemic heart disease should use this medication cautiously. The Hydrochlorothiazide component may sensitize the skin to sunlight, increasing the risk of skin cancer; therefore, sun exposure should be avoided during use, and the skin should be monitored periodically. This medication lowers blood pressure, and symptoms such as dizziness, hypotension, and fainting may occur. Electrolyte imbalances can occur, making it important to regularly check the levels of potassium, sodium, and other electrolytes through blood tests. Particular caution is essential for patients with impaired kidney function or those who are dehydrated or sodium deficient, as there is a risk of hypotension or kidney failure; improving these conditions before taking the medication is crucial. This medication may interact with other antihypertensives, diuretics, lithium, and non-steroidal anti-inflammatory drugs; it is essential to inform healthcare professionals of any medications being taken. Dizziness or drowsiness may occur when driving or operating machinery, so caution is advised, and such activities should be avoided if symptoms are present. Overdose may result in hypotension, electrolyte abnormalities, dehydration, and it is vital to adhere to the recommended dosage; seek immediate medical attention if adverse symptoms occur. This medication is not recommended for use in children under 18 years of age, as its safety and efficacy have not been established.

Serious side effects

Hives, angioedema, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with fever, blisters, skin peeling, mucosal pain in the mouth/eyes, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory anomalies accompanying cough and fever, respiratory issues, jaundice (yellowing of the skin or eyes), generalized lethargy, liver abnormalities (jaundice), sudden

Mild side effects

Dizziness, diarrhea, cough, pharyngitis, sinusitis, hypokalemia, hyperuricemia, hyponatremia, anxiety, depression, insomnia, sleep disturbances, fainting, paresthesia, visual disturbances, blurred vision, vertigo, tachycardia, arrhythmia, hypotension, orthostatic hypotension, dyspnea, respiratory distress, pneumonia, pulmonary edema, diarrhea, dry mouth, abdominal distension, abdominal pain, constipation, indigestion, vomiting, liver function abnormalities/liver disorders, erythema, pruritus, rash

Store this medication in a tightly closed container to protect it from air and moisture. The storage temperature should be maintained between 1 to 30 degrees Celsius (room temperature). Proper storage will help maintain the medication's efficacy and ensure safe use.

Appearance

White or off-white elongated tablet

Package unit

30 tablets (10 tablets/Alu-Alu * 3)