Coxib Capsule 200 mg (Celecoxib)

Adult dose

The minimum recommended dose of this drug should be adjusted for each patient, and it may be administered with or without food. Osteoarthritis (degenerative arthritis): Administer 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. Rheumatoid arthritis: Administer 100 mg or 200 mg of celecoxib per dose twice daily. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or divide the dose into 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks of treatment with 400 mg per day, other treatment options should be considered. Acute pain and primary dysmenorrhea: The recommended initial dose is 400 mg of celecoxib; if necessary, an additional 200 mg may be administered on the first day of treatment. From the second day of treatment, the recommended dose, if needed, is 200 mg per dose twice daily. For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

Patients who consume more than three alcoholic drinks daily should consult with their doctor or pharmacist before taking this medication, as there is a risk of gastric bleeding. This drug may increase the risk of cardiovascular diseases, therefore patients with cardiovascular problems or risk factors, such as myocardial infarction or stroke, should use the minimum dose for a short duration and inform healthcare professionals immediately if cardiovascular symptoms occur. Serious gastrointestinal issues such as perforation, ulceration, or bleeding may occur, thus individuals with a history of gastrointestinal diseases or the elderly should take special precautions, and seek immediate treatment if symptoms such as epigastric pain, black stools, or vomiting blood arise. Individuals allergic to this medication or who have previously shown hypersensitivity to sulfonamides, aspirin, or other non-steroidal anti-inflammatory drugs, as well as those with severe liver or kidney disease, active peptic ulcers, heart failure, pregnant or potentially pregnant women, and nursing mothers should not take this medication. Individuals with reduced liver or kidney function, asthma, hypertension, heart failure, diabetes, and the elderly should consult with their doctor and use this medication carefully. While using this drug, side effects such as headache, dizziness, dyspepsia, diarrhea, skin rash, swelling, exacerbation of hypertension, and liver function abnormalities may occur, and if side effects persist or are severe, medical attention should be sought immediately. This drug is metabolized in the liver; therefore, it may affect liver function or interact with other medications, particularly when taken with CYP2C9 inhibitors or inducers, anticoagulants, diuretics, and antihypertensive medications. It should be taken according to a doctor's instructions. Pregnant women or those planning to become pregnant should avoid this medication due to its potential effects on the fetus; nursing mothers should also consult with their doctor or stop breastfeeding while taking this medication. The safety and efficacy for children and adolescents have not been established, hence it is advisable not to use this medication. The elderly are at increased risk for impaired kidney, liver, or heart function, necessitating extra caution during administration, and any adverse reactions should be closely monitored post-treatment. Regular blood tests and liver and kidney function tests should be performed while on this medication to monitor for abnormalities; if any abnormal findings are discovered, treatment should be ceased immediately. In cases of overdose, symptoms such as lethargy, drowsiness, nausea, vomiting, and abdominal pain may occur, necessitating immediate emergency treatment. This medication should be stored out of reach of children, and transferring it to other containers should be avoided due to the risk of quality deterioration and accidents.

Gastrointestinal bleeding, cardiovascular thromboembolic reactions, myocardial infarction, stroke, upper and lower gastrointestinal perforations, ulcers, bleeding, bronchitis, sinusitis, upper respiratory infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, liver enzyme elevation, itching, rash, hives, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial edema, influenza-like illness, injury, injury, headache, leg cramps, tension, sensory decline, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, loss of taste, allergy exacerbation, allergic reactions, weakness, chest pain, fluid retention, systemic edema, facial swelling, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reactions, angioedema, loss of appetite, increased appetite, depression, neuro-excitability, drowsiness, fatal intracranial hemorrhage, hallucinations, epilepsy exacerbation, upper respiratory infections, sinusitis, pharyngitis, rhinitis, bronchitis, bronchial spasms, exacerbated bronchial spasms, shortness of breath, laryngitis, pneumonia, nosebleed, speech difficulties, vesicular dermatitis, dermatitis, nail disease, photo-sensitivity reactions, pruritus, erythematous rash, maculopapular rash, skin diseases, dry skin, increased sweating, erythema multiforme, exfoliative dermatitis, mucocutaneous syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, eczema, lipoma, allergic dermatitis, petechiae, dandruff, drug rash associated with eosinophilia and systemic symptoms, arrhythmia, left ventricular hypertrophy, angina, unstable angina, coronary artery disorders, myocardial infarction, heart failure, palpitations, tachycardia, aortic valve insufficiency, hematoma, bradycardia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral necrosis, thrombophlebitis, vasculitis, deep vein thrombosis, cerebral hemorrhage, solitary lesions, wound infections, gingivitis, herpes simplex, shingles, bacterial infections, fungal infections, soft tissue infections, viral infections, moniliasis, genital moniliasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasms, chest pain, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, deafness, liver function abnormalities, elevated ALT, elevated AST, increased γ-GTP, elevated ALP, positive urinary urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, loss of appetite, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical tension, synovitis, tendinitis, myositis, fractures, tendon rupture, back pain, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleed, thrombocytopenia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, angioedema, contact dermatitis, injection site reactions, skin nodules, ageusia, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, urinary tract infections, blurred vision, cataracts, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis, menstrual disorders, chest pain, anaphylactic reactions, hallucinations, cerebral hemorrhage, aseptic meningitis, loss of taste, loss of smell, conjunctivitis, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, liver failure, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, jaundice, photo-sensitivity reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash associated with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, fixed drug eruptions, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, microcystic glomerulonephritis, female infertility

This medication may be sensitive to air and moisture, hence it should be stored in a tightly sealed container. It is best to keep it at room temperature between 15 degrees Celsius and 30 degrees Celsius. Proper storage helps maintain the efficacy of the drug.

Appearance

White or off-white powder in an opaque white hard capsule

Package unit

30 capsules/bottle, 100 capsules/bottle