J-Phase Tablet 10 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

As donepezil hydrochloride, administer 5 mg once daily before bedtime. For 4 to 6 weeks, administer the 5 mg dose, and after evaluating clinical response, it can be increased up to 10 mg. When increasing to 10 mg daily, be cautious of gastrointestinal adverse reactions. Underweight women aged 85 and older should not exceed 5 mg daily and need careful monitoring.

Child dose

There is no experience using it for children.

This drug contains donepezil hydrochloride as its active ingredient and is used to treat symptoms of Alzheimer's type dementia. First, this medication should not be administered to patients who are allergic to donepezil hydrochloride or any of its components, to pregnant or potentially pregnant women, and to nursing mothers. Furthermore, patients with genetic lactose intolerance or glucose-galactose malabsorption should also avoid this medication. Patients with heart diseases, particularly those with bradycardia or heart conduction disorders, should use this medication with caution as it may cause cardiac issues such as bradycardia or arrhythmias. Those taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should be cautious as increased gastric acid secretion may worsen ulcers. Patients with a history of asthma or obstructive pulmonary disease should be careful, as this medication may increase bronchoconstriction and mucus secretion, worsening symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should also be cautious as symptoms may worsen with this medication. This medication can cause a variety of adverse reactions, which in severe cases may include syncope, abnormal heart rhythms, gastrointestinal bleeding, liver dysfunction, intracranial hemorrhage, seizures, and myopathy. Common side effects reported include dizziness, nausea, vomiting, diarrhea, insomnia, hallucinations, anxiety, drowsiness, and skin rashes. If any of these adverse reactions occur, consultation with a physician should be sought immediately. This medication can affect the heart; therefore, patients with a history of heart disease or those at risk for QT interval prolongation should undergo regular ECG monitoring to check their condition. Additionally, this medication may interact with other drugs, so it is essential to consult with a physician or pharmacist regarding the use of any other medications while taking this drug. Care should be taken when combined with antibiotics, antidepressants, antiarrhythmics, and antipsychotics. Pregnant or nursing women should generally not use this drug; if absolutely necessary, use should be under strict supervision by a specialist. The safety of this drug for children has not been established, so it is advisable not to administer it to minors. In case of overdose, serious symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur, necessitating immediate medical attention and treatment, potentially using atropine as an antidote. Finally, this medication should be stored out of reach of children and should not be transferred to other containers, as this is important for maintaining quality.

Serious side effects

Syncope, bradycardia, heart block, QT interval prolongation, myocardial infarction, heart failure, peptic ulcer, perforated duodenal ulcer, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizures, intracranial hemorrhage, cerebrovascular disorders, extrapyramidal disorders, neuroleptic malignant syndrome, rhabdomyolysis, dyspnea, acute pancreatitis, acute renal failure, unexplained sudden death, cardiac arrest, severe edema accompanied by elevated blood pressure or urinary abnormalities, serious kidney

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• pain
• dental pain
• facial flushing
• lethargy

This drug should be stored in a sealed container to prevent exposure to air and moisture, preferably at room temperature between 1°C and 30°C. Storing it this way helps maintain the drug's efficacy.

Appearance

Yellow, round, film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle