Piromet Tablet 15/850 mg (Pioglitazone Hydrochloride, Metformin Hydrochloride)

Adult dosage

The dosage of this medication should be individualized based on efficacy and tolerability, not exceeding a total of pioglitazone 30mg and metformin 2500mg. The initial dose is based on the patient's current therapeutic regimen. Start with one tablet daily and gradually adjust the dose based on treatment response. This medication should generally be taken with meals, which can reduce gastrointestinal adverse effects due to metformin.

This medication may cause severe lactic acidosis, so those with impaired kidney function or heart disease should exercise special caution. If sudden symptoms of heart failure, weight gain, shortness of breath, or swelling occur while taking this medication, consult a physician immediately. This medication should not be administered to patients with impaired liver function, and if liver dysfunction is suspected, regular liver function tests should be performed. This medication should not be used in patients with a history of bladder cancer or active bladder cancer. Women who are pregnant or breastfeeding should not take this medication, and premenopausal women should use appropriate contraception to avoid the possibility of pregnancy while on this medication. Elderly patients may have reduced kidney function, so the dosage of this medication should be carefully adjusted, and regular kidney function tests should be performed. Excessive alcohol consumption should be avoided while taking this medication, and temporary discontinuation may be required in cases of dehydration, severe infection, or before and after surgery. Symptoms of hypoglycemia may occur, so caution is advised when skipping meals or engaging in vigorous exercise. This medication can interact with other medications, so if you are taking other drugs, be sure to inform your physician or pharmacist. If any unusual symptoms or discomfort persists or worsens, contact healthcare professionals immediately.

Serious side effects

Lactic acidosis, hypoglycemia, severe allergic reactions, liver issues (jaundice), heart failure, congestive heart failure, edema, severe swelling or urination abnormalities, severe neurological symptoms, severe skin reactions, bladder cancer, macular edema, fatal and non-fatal liver failure, myocardial infarction, stroke, acute coronary syndrome, cardiovascular interventions, major vascular complications, fractures, hypoglycemia, hypotension, resistant bradyarrhythmia, electrolyte imbalance.

Mild side effects

• Upper respiratory tract infection
• diarrhea
• nausea
• headache
• urinary tract infection
• sinusitis
• dizziness
• lower extremity edema
• weight gain
• anemia

This medication should be stored in a tightly closed container to prevent exposure to air and moisture. It is also safe to store the medication at room temperature, between 1 to 30 degrees Celsius, avoiding extremely hot or cold places.

Appearance

White to whitish rectangular film-coated tablets

Package unit

30 tablets (10 tablets/PTP*3)