Linadia Duo Tablets 2.5/500 mg

Adult dose

The dosage of this medication is determined based on the maximum recommended doses of each component, specifically Linagliptin 2.5 mg and Metformin 1000 mg, not exceeding two doses per day, considering each patient's current treatment regimen, efficacy, and tolerability. This medication is administered twice daily with meals. 1. If currently not treated with Metformin: Take one tablet twice a day, and the dosage may be increased to one tablet twice a day, up to a maximum of two doses per day.

This medication may cause serious side effects such as lactic acidosis, so caution is needed. Lactic acidosis is a dangerous condition that occurs when lactic acid builds up excessively in the body, which can be life-threatening without immediate treatment. This medication should not be administered to patients with severely impaired kidney function, poor liver function, weakened heart or lung function, or those with acute infections or dehydration. Additionally, women who are pregnant or breastfeeding should not take this medication. The risk of hypoglycemia exists; therefore, when used with insulin or sulfonylurea class medications, careful monitoring of blood sugar changes is essential. Elderly patients with diminished kidney function should have their kidney function checked regularly and adjust the dosage if necessary. Acute pancreatitis or skin blistering conditions may occur during medication; thus, if severe abdominal pain or skin abnormalities arise, consult a doctor immediately. Gastrointestinal discomfort symptoms (abdominal pain, diarrhea, vomiting, etc.) can occur frequently, so it is recommended to take the medication with meals or after meals. Be cautious of drug interactions, especially when taking other medications that could affect kidney function; close monitoring of kidney function is required. If receiving iodine contrast agents for radiological exams, this medication should be discontinued before and after the examination until kidney function stabilizes. For surgical procedures, this medication should be stopped 48 hours before surgery and can be resumed once kidney function has recovered post-surgery. If planning to become pregnant or if already pregnant, it is recommended to manage blood sugar with insulin therapy instead of this medication. The safety of this medication in children and adolescents has not been established, so it is not recommended for patients in this age group. This medication should be stored out of reach of children in a cool, dry place.

Serious side effects

Hives, angioedema, lactic acidosis, pancreatitis, liver dysfunction (including hepatitis, liver function test abnormalities, jaundice symptoms), bullous pemphigoid, acute myocardial infarction, heart failure, unstable angina, acute kidney injury, end-stage renal disease, acute cholangitis, acute cholecystitis, cholangitis, cholelithiasis, acute pyelonephritis, sepsis, pneumonia, asthma attacks, respiratory distress, kidney transplant failure, cerebral infarction, visual disturbances, confusional state, seizures, paralysis, heart failure

Mild side effects

• Pharyngitis
• hypersensitivity
• vitamin B12 deficiency
• hypoglycemia
• dysgeusia
• cough
• decreased appetite
• diarrhea
• constipation
• nausea

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. Additionally, to maintain drug efficacy, it is important to store it at a cool room temperature, specifically between 1 to 30 degrees Celsius.

Appearance

Bright yellow, oval, biconvex film-coated tablets

Package unit

30 tablets/bottle, 60 tablets/bottle, 100 tablets/bottle, 200 tablets/bottle