Diseren Capsule (Diacerein)

Adult dose

Adults: Administer 50~100mg of diacerein orally in 1~2 divided doses after meals. Adjust the dose as appropriate according to symptoms. For patients with a history of loose stools or diarrhea, an initial dose of 50mg once daily for the first 2~4 weeks is recommended, followed by 50mg twice daily.

This medication should not be used by patients with inflammatory bowel diseases. For example, individuals suffering from conditions like ulcerative colitis or Crohn's disease should not take this medication. Patients with intestinal obstruction syndrome or those with unexplained abdominal pain should also refrain from taking this medication. Individuals allergic to this medication, its components, or Rhein derivatives should avoid taking it. Patients with liver disease or those with a history of liver disease should not use this medication. Children under 15 years old should not take this medication, nor should those with lactose intolerance or certain genetic digestive disorders. Patients with a history of small intestine or colon diseases should use this medication cautiously. Women who are pregnant or breastfeeding should avoid using this medication if possible. Elderly patients over 65 years should reduce their dosage and strictly follow the physician's directions. Taking this medication may cause gastrointestinal symptoms such as diarrhea, soft stools, and abdominal pain. Prolonged usage can lead to serious issues like gastrointestinal bleeding, ulcers, and perforation. If diarrhea worsens, dehydration and electrolyte imbalance may occur, so caution is needed. Skin symptoms such as itching, rash, or eczema may appear, and liver function may be affected, leading to elevated liver enzyme levels. When taking for a prolonged period, always follow the physician's instructions, and if diarrhea occurs, discontinue the medication immediately and consult a doctor. Especially, it is advisable to avoid taking it with laxatives. Due to the risk of liver damage, liver function should be closely monitored, and caution is required when used with other medications that may burden the liver. It is recommended to limit alcohol consumption. Taking this medication with antacids containing calcium, magnesium, or aluminum, or with salts may hinder the absorption of this medication, so it should be taken at least 2 hours apart. Using it with diuretics may enhance the diuretic effect, leading to risks of dehydration and hypokalemia, hence caution is advised. Care should be taken because using it with cardiac glycosides may increase the risk of arrhythmias. It is preferable not to use this medication in pregnant women as it may affect fetal bone formation, and breastfeeding women should also avoid taking it. In case of overdose, severe diarrhea may occur, and appropriate treatment such as electrolyte supplementation should be received.

Diarrhea, loose stools, abdominal pain, gastrointestinal disorders (bleeding, ulcers, and perforation), pigmentation of the rectal mucosa, itching, rash, eczema, elevated serum liver enzymes

This medication may be sensitive to air or moisture, so it should be stored in a tightly closed container. It is advisable to keep it at room temperature between 1 to 30 degrees Celsius. Keeping it this way maintains the effectiveness of the medication and allows for safe use.

Appearance

A hard capsule with white upper part and yellow lower part containing brownish yellow contents

Package unit

30 capsules/bottle, 500 capsules/bottle