Levogrin Tablets (Levosulpiride)

Adult dose

Adults: Administer levosulpiride 25 mg orally 3 times daily before meals.

This medication should not be used by women who are pregnant or may become pregnant and by women who are breastfeeding. It is not administered to patients with gastrointestinal bleeding, mechanical obstruction, or perforation as this medication may stimulate gastrointestinal motility and pose risks. It should also not be given to patients with pheochromocytoma that may induce hypertension due to tumors. Patients with known allergic reactions or intolerances to this medication should avoid its use. This medication is also unsuitable for patients with liver disease and for patients in the manic phase or hypomanic phase of bipolar disorder. Patients with malignant breast disease associated with breast tissue dysplasia should also not receive this medication. This medication contains lactose, so it should not be given to patients with lactose intolerance or related genetic disorders. Caution should be exercised when administering to patients with hypertension, children, and elderly patients, especially since children may easily experience extrapyramidal symptoms and overdose should be avoided. It may present symptoms such as amenorrhea, hyperprolactinemia, gynecomastia due to endocrine abnormalities, necessitating careful observation of the patients. Extrapyramidal symptoms such as tremors, tongue twisting, and anxiety may rarely occur, and if they do, the medication should be discontinued immediately. Prolonged use may lead to involuntary movements around the mouth, so caution is needed. Gastrointestinal side effects may include dry mouth, heartburn, nausea, vomiting, diarrhea, and constipation. Cardiovascular side effects like hypertension or arrhythmias may also arise, so caution is required. A severe side effect known as neuroleptic malignant syndrome has been reported, and if symptoms appear, medication administration must stop immediately and emergency treatment should be sought. Rarely, skin rashes or swelling may occur, and symptoms such as flushing, lethargy, insomnia, drowsiness, dizziness, staggering, erectile dysfunction have also been reported. It is advisable to avoid driving vehicles or operating machinery requiring attention while on this medication. Cardiac-related side effects may include QT interval prolongation or ventricular arrhythmias; thus, patients at risk for heart disease should exercise caution. Interactions with other medications may occur, so especially when used in combination with anticholinergics, narcotic analgesics, digitalis preparations, benzamide derivatives, psychotropic medications, QT-prolonging drugs, and drugs causing electrolyte disorders, careful monitoring is required. The use in pregnant and breastfeeding women is not advisable due to lack of established safety. In elderly patients, renal function decline may prolong the drug’s presence in the body, so adjustment of dosage and administration intervals while monitoring for side effects is necessary. This medication has anti-emetic properties and may mask vomiting symptoms from other causes, hence careful monitoring and assessment during its use are required. Animal studies have reported risks of decreased reproductive function and tumor formation, indicating care is needed with long-term, high-dose use.

• Amenorrhea
• galactorrhea
• gynecomastia
• tremor
• tongue twisting
• anxiety
• involuntary movements around the mouth
• thirst
• heartburn
• nausea

Store this medication in a tightly sealed container to prevent exposure to air or moisture. Additionally, it is best to keep the medication at room temperature, between 1 and 30 degrees Celsius, avoiding extremes of heat or cold.

Appearance

White round tablets

Package unit

30 tablets/bottle, 100 tablets/bottle, 1000 tablets/bottle