Linagliptin Metformin Duo Tablet 2.5/500 mg

Adult dose

The dosage of this medication is determined based on the patient's treatment regimen, efficacy, and tolerance, not exceeding Linagliptin 2.5 mg and Metformin 1000 mg twice a day. This medication is to be taken twice daily with meals. 1. For patients not previously treated with Metformin: An initial dose of 2.5/500 mg is taken twice daily, with a maximum increase to 2.5/1000 mg.

This medication may cause serious side effects, such as lactic acidosis, so patients with poor kidney function or heart disease, or liver dysfunction should not use it. Additionally, patients with allergies to the ingredients of this medication or patients with type 1 diabetes, acute infections, or dehydration should not take it. There is a risk of hypoglycemia when used in conjunction with sulfonylureas or insulin, so caution is necessary, and blood glucose levels should be closely monitored. Kidney function should be regularly checked, and extra caution is necessary for elderly patients or those at risk for decreased kidney function. Rare side effects such as acute pancreatitis or bullous pemphigoid can occur, so if there are persistent and severe abdominal pains or blisters on the skin, a doctor should be informed immediately. Furthermore, vitamin B12 levels may decrease, thus regular blood tests are necessary during long-term use. This medication is not recommended for women who are pregnant or breastfeeding, and should be avoided if pregnancy is planned. Safety and effectiveness in children and adolescents have not been established, therefore those populations are discouraged from using this medication. It is advisable to avoid alcohol intake during the medication period, and potential interactions with other drugs should be discussed with a doctor or pharmacist. In case of overdose, there is a risk of lactic acidosis, and immediate medical treatment is required; the medication should be stored out of reach of children and kept away from moisture.

Serious side effects

Hives, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, jaundice (yellowing of skin or eyes due to liver dysfunction), acute myocardial infarction, angina, congestive heart failure, unstable angina, cardiac arrest, acute kidney injury, end-stage renal disease, acute cholangitis, acute cholecystitis, cholangitis, acute pyelonephritis, sepsis, pneumonia, asthma, dyspnea, chest tightness, difficulty breathing, cough accompanied by fever, acute pancreatitis

Mild side effects

• Pharyngitis
• hypersensitivity
• reduction and deficiency of vitamin B12
• taste disorder
• cough
• decreased appetite
• diarrhea
• constipation
• nausea
• vomiting

This medication is sensitive to air and humidity and should be stored in a tightly sealed container. It is also important to keep it at room temperature between 1 degree to 30 degrees Celsius to maintain its effectiveness.

Appearance

Bright yellow, bilaterally convex, film-coated tablet in a round shape

Package unit

10 tablets/bottle, 30 tablets/bottle, 60 tablets/bottle, 100 tablets/bottle, 200 tablets/bottle, 30 tablets/box [(10 tablets/PTP×3)]