Iselrin Capsule (Diacerein)

Adult dosage

Adults: Administer 50∼100mg of diacerein orally in 1∼2 divided doses after meals. Adjust the dose as appropriate according to symptoms. For patients with a history of loose stools or diarrhea, an initial dose of 50mg once daily for the first 2-4 weeks is recommended, followed by 50mg twice daily.

This medication should not be used in patients with inflammatory bowel diseases. For example, patients with ulcerative colitis or Crohn's disease should not take this medication. Additionally, patients with intestinal obstruction syndrome or unexplained abdominal pain should also avoid this medication. Patients who are allergic to this medication or its components, as well as those allergic to Rhein-related medications, should refrain from using it. Patients with liver disease or a history of liver disease should also avoid this medication. This medication is not to be used in children under 15 years of age. As this medication contains lactose, patients with genetic issues such as lactose intolerance, galactose intolerance, or glucose-galactose malabsorption should not take it. Patients with a history of small intestine or colon diseases should use this medication cautiously. Since this medication belongs to the anthraquinone class, special caution is needed. Women who are pregnant or breastfeeding should also exercise caution when using this medication and should avoid it if possible. It is safer for elderly patients over 65 years old to reduce the dosage of this medication. Taking this medication can lead to gastrointestinal symptoms such as diarrhea, loose stools, and abdominal pain. Prolonged use may cause serious issues like gastric bleeding, ulcers, or perforation, hence caution is advised. If diarrhea becomes severe, dehydration or electrolyte imbalances may occur, and in such cases, immediate discontinuation and consultation with a doctor is advised. Skin reactions such as itching, rash, or eczema are common. It may affect liver function and elevate liver enzyme levels, so it is advisable to periodically check liver health. When using this medication for a long time, it is essential to follow a doctor's instructions, and if diarrhea occurs, it should be discontinued immediately and medical advice sought. The use of anti-diarrheal medications simultaneously should be avoided. If symptoms of liver damage occur, the medication should be stopped immediately, following the doctor's advice, and alcohol should be avoided. Taking antacids that contain calcium, magnesium, or aluminum, or salt may interfere with the absorption of this medication, so they should be taken with a minimum interval of 2 hours. Caution should be exercised when using it with diuretics as the diuretic effect may be increased, heightening the risk of dehydration and hypokalemia. If taken together with cardiac glycosides, the risk of arrhythmias may increase, so consultation with medical personnel is advisable. Animal studies have reported that this medication may affect fetal bone formation, and there is insufficient safety data for humans. Because it may be secreted in small amounts in breast milk, it is advisable for pregnant or breastfeeding women to avoid using this medication. In case of an overdose, severe diarrhea may occur, and symptomatic treatment such as electrolyte replenishment may be necessary.

Diarrhea, loose stools, abdominal pain, gastrointestinal disorders (bleeding, ulcers, and perforation), pigmentation of the rectal mucosa, itching, rash, eczema, elevation of liver enzymes in serum

This medication should be stored in a tightly sealed container to protect it from exposure to air or moisture. It is essential to maintain the storage temperature between 1 to 30 degrees Celsius at room temperature. This will help preserve the medication's effectiveness and prevent deterioration.

Appearance

Hard capsule with a white upper part and yellow lower part filled with brownish-yellow content

Package unit

30 capsules/bottle, 500 capsules/bottle