Peroxyjeong 40mg (Febuxostat)

Adult dosage

1. Adults Administer this medicine at a dose of 40mg or 80mg once daily, with or without food. As this medicine acts very rapidly, recheck the serum uric acid concentration after 2 weeks. The treatment goal is to lower and maintain the serum uric acid concentration below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dose adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). 3. Patients with hepatic impairment No specific dose adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This medication may increase the risk of cardiovascular mortality in patients with cardiovascular disease, so it should be used cautiously in patients with a history of cardiac conditions. It should not be used in patients with allergies to any of the active ingredients or excipients, patients taking certain anticancer drugs, or those with genetic issues such as lactose intolerance. Patients with liver disease, thyroid dysfunction, heart failure, ischemic heart disease, organ transplant recipients, etc., require regular monitoring, including liver function tests, when administering this drug. There may be side effects such as liver function abnormalities, diarrhea, headaches, rashes, fatigue, and dizziness while taking this medication. Consult a physician if these symptoms occur. Do not start this medication during an acute gout attack, and do not discontinue it if an attack occurs. Appropriate gout treatment should be used in conjunction with this medication. This medication may interact with other drugs, so caution is required, especially when used in combination with mercaptopurine, azathioprine, theophylline, etc., and inform the doctor when taking medications. It is recommended that pregnant or breastfeeding women do not take this medication, and it is not advised for children and adolescents under 18 due to a lack of experience in its use. No specific cases of overdose have been reported, but treatment should be based on symptoms in the event of an overdose. This medication should be kept out of reach of children, and no special storage conditions are required. Caution is required when driving or operating machinery as drowsiness or dizziness may occur. If any cardiovascular symptoms or adverse reactions occur during the use of this medication, it is important to consult healthcare personnel immediately.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, joint pain, limb pain, gout, muscle pain, pruritus, shortness of breath, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, ECG abnormality, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, flatulence, increased bowel frequency, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, hematochezia, oral ulcer, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, mood disturbances, gait disturbances, influenza-like symptoms, mass, pain, thirst, cholelithiasis, diabetes mellitus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, reduced appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramps, muscle single contraction, muscle contraction, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance disturbances, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, olfactory reduction, heat ischemic disease, drowsiness, mental disorder, migraine, sensory disturbances, sleepiness, transient ischemic attack, tremor, restlessness, anxiety, depression, insomnia, excitability, decreased libido, neuropsychiatric irritability, panic attack, personality changes, hematuria, nephrolithiasis, increased urination, proteinuria, renal failure, kidney dysfunction, urinary urgency, urinary incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, cough, shortness of breath, epistaxis, nasal dryness, sinus hypersecretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin eruption, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechial hemorrhage, photosensitivity, itching, purpura, skin discoloration, pigmentation changes, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, activated partial thromboplastin time prolonged, increased creatinine, decreased bicarbonate, increased sodium, EEG abnormality, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, increased creatinine, increased blood urea, increased blood urea to creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased white blood cell count, decreased white blood cell count, abnormal coagulation test, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, positive urinary leukocytes, positive urinary protein, contusion, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, drug reaction with eosinophilia and systemic symptoms, liver failure, jaundice, hepatic impairment, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly closed container to protect it from air and moisture. Additionally, avoid very hot or very cold places, and it is best stored at room temperature between 1 to 30 degrees Celsius.

Appearance

White to slightly yellow circular film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle