Xoneal Tablet 5/80/10 mg

Adult dose

This drug is taken as 1 tablet daily with water. It is recommended to take it at the same time each day (e.g., before breakfast) if possible. For the amlodipine/losartan combination, doses of 5/80 mg, 5/160 mg, or 10/160 mg are administered depending on blood pressure control status. Rosuvastatin can be taken at any time of the day, regardless of meals, as a single daily dose. The initial dose is 5 mg, and the maintenance dose is 10 mg.

This drug can cause severe harm to the fetus and newborn when used during the second and third trimesters of pregnancy; therefore, it should be discontinued immediately if pregnancy is confirmed. Women who are pregnant or could become pregnant, as well as nursing mothers, should not use this drug. Patients with severe impairment of liver or kidney function should also refrain from taking this medication. Caution is needed for diabetic patients or those with moderate to severe renal impairment when used in conjunction with specific components. Patients with a history of muscle-related diseases or angioedema should also avoid taking this drug. Patients who are depleted of sodium or fluid should improve their condition prior to taking the drug and closely monitor blood pressure and symptoms during treatment. Blood potassium levels need to be frequently checked for patients with high potassium levels or those taking drugs that may increase potassium. Renal transplant patients or those with renal artery stenosis should carefully monitor kidney function during the use of this drug. Patients with heart failure or after myocardial infarction require careful monitoring, including assessments of renal function. This drug can be used in the elderly; however, particularly in those aged 75 and older, starting with a lower dose and gradually increasing is advisable. Caution is advised when driving or operating machinery as dizziness or fatigue may occur. Some of this drug's components may burden the liver and kidneys, thus regular tests of liver and kidney function are recommended. Additionally, if symptoms such as muscle pain or weakness occur, the patient should inform their doctor immediately, and blood tests may be required to check for muscle damage. As interactions with other medications may occur, it is essential to inform healthcare providers about any other drugs being taken. This drug contains certain dye components, so patients with allergies to these should exercise caution. Pregnant or nursing women should refrain from taking this drug, and women planning to become pregnant should use appropriate contraceptive methods. Safety and effectiveness have not been established for children, so it is not recommended. In cases of overdose, severe hypotension, shock, etc. can occur, necessitating immediate emergency treatment, while dosage adjustment and monitoring remain vital.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosae, difficulty or shortness of breath, asthma attacks, respiratory abnormalities with cough and fever, jaundice (yellowing of the skin or eyes), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, vision disturbances, paralysis, urination issues.

Mild side effects

• Peripheral edema
• warmth
• increased ALT
• increased AST
• increased serum creatinine
• flank pain
• throat pain
• dizziness
• sensory impairment
• nasopharyngitis

This drug should be kept in a tightly closed container to avoid exposure to air or moisture and should be stored at room temperature between 1 to 30 degrees Celsius. Proper storage can help maintain the effectiveness of the medication for a longer period.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle