Tragliptin Duo Tablet 2.5/500 mg

Adult dose

This medication is administered in two doses daily with meals. 1. In cases not previously treated with Metformin: Start with this medication 2.5/500 mg twice daily, 1 tablet per dose, and may increase to 2.5/1000 mg twice daily, 1 tablet per dose. 2. In cases switching from combination therapy with Linagliptin and Metformin: The initial dose should be the same as the dose of Linagliptin and Metformin previously taken.

This medication contains Metformin hydrochloride, which can cause serious side effects such as lactic acidosis, and caution is required. Lactic acidosis is rare but can be fatal, so this medication should be discontinued in the event of sudden kidney function deterioration, cardiovascular disease, infections, or other risky situations. Additionally, this medication should not be administered to certain patients, such as those with allergies to its components, type 1 diabetes patients, patients with severe renal impairment, those in acute alcohol intoxication, pregnant women, or nursing mothers. When using this medication, there is a risk of hypoglycemia, especially when combined with other antidiabetic agents, so careful monitoring of blood sugar status is necessary. Immediate appropriate measures should be taken if hypoglycemic symptoms occur. Since kidney function plays an important role, routine kidney function tests should be performed before and during treatment, and if kidney function declines, discontinuation or dosage adjustment may be necessary. Patients with impaired heart function should use this medication with caution, and administration should generally be avoided in cases of acute cardiac disease or heart failure. Using this medication in conjunction with iodinated contrast agents used during radiological examinations can increase the risk of renal dysfunction and lactic acidosis, so this medication should be discontinued for a certain period before and after the examination. Patients scheduled for surgery should discontinue this medication 48 hours before the operation and resume only after confirming normal recovery of kidney function post-surgery. During the use of this medication, acute pancreatitis or skin diseases such as bullous pemphigoid may occur, so if symptoms such as abdominal pain, skin rash, or blisters appear, it is advisable to consult a doctor immediately. The Metformin component may decrease vitamin B12 levels, so regular checks for vitamin B12 deficiency are necessary in cases of prolonged use. It is recommended that women who are pregnant or planning to become pregnant do not use this medication, and it should also be avoided during breastfeeding. The safety and efficacy of this medication have not been established for children under 10 years of age and adolescents, so it is not recommended for them. Elderly patients are more likely to have decreased kidney function, so it is important to monitor kidney function frequently and to provide treatment at the minimum effective dose. This medication may interact with other drugs, so if other medications are being taken, it is essential to inform the doctor or pharmacist. In case of overdose, lactic acidosis may occur, requiring immediate hospitalization for treatment, and blood dialysis may be necessary. For storage, it should be kept out of reach of children, protected from moisture, and stored in its original container to maintain efficacy.

Serious side effects

• Urticaria
• angioedema
• lactic acidosis
• pancreatitis
• bullous pemphigoid
• abnormal liver function
• hepatitis
• angina pectoris
• acute myocardial infarction
• unstable angina

Mild side effects

Hypoglycemia, altered taste, cough, decreased appetite, diarrhea, constipation, nausea, vomiting, abdominal pain, formation of oral ulcers, abnormal liver function tests, hepatitis, itching, erythema, rash, severe and disabling arthralgia, rhabdomyolysis, increased lipase, increased amylase, decreased and deficient vitamin B12, decreased hemoglobin, increased blood potassium, increased blood creatinine, increased blood creatine phosphokinase activity, anxiety, mood disturbances, insomnia

This medication should be stored in a tightly closed container, protected from air and moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. By doing so, the effectiveness of the medication can be preserved for a long time.

Appearance

Bright yellow oval film-coated tablet with a double convex shape

Package unit

10 tablets/bottle, 30 tablets/bottle, 60 tablets/bottle, 100 tablets/bottle, 200 tablets/bottle, 30 tablets/box (10 tablets/PTP x 3)