Donecare 10 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. After administering the 5 mg dose for 4 to 6 weeks, assess clinical response and consider increasing up to 10 mg. When increasing to 10 mg per day, administer while paying attention to gastrointestinal side effects. Underweight females aged 85 or older should not exceed 5 mg per day and require careful monitoring.

Child dose

No experience with use in children.

This medication contains donepezil hydrochloride and is used for the treatment of Alzheimer's dementia symptoms. Firstly, do not take this medication if you are allergic to donepezil or piperidine derivatives, or any ingredients contained in this medication. It is also safe not to use this medication during pregnancy or if you are a breastfeeding woman. Additionally, since it contains lactose, people with genetic issues such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should avoid taking it. Patients with heart disease or conditions like bradycardia, heart conduction disorders should be cautious as this medication may stimulate the vagus nerve, leading to slow heart rate or arrhythmia. Persons taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should use it cautiously due to possible increased gastric acid secretion worsening symptoms. Patients with a history of asthma or obstructive pulmonary disease also need caution as bronchoconstriction and increased mucus secretion can worsen symptoms. Those with extrapyramidal disorders such as Parkinson's disease should also be careful as symptoms may worsen. This medication contains Yellow No. 5, so individuals allergic to this substance or highly sensitive to it should take it cautiously. During administration, various adverse reactions may appear; in severe cases, syncope, heart block, myocardial infarction, gastrointestinal bleeding, liver dysfunction, seizures, muscle cramps, respiratory distress, acute pancreatitis, and acute renal failure may occur. In addition, various side effects such as hallucinations, anxiety, insomnia, dizziness, diarrhea, nausea, vomiting, myalgia, skin rashes have been reported. In particular, cardiovascular side effects such as bradycardia, palpitations, atrial fibrillation may occur, so patients with heart disease may require regular ECG examinations. Common gastrointestinal side effects include diarrhea, nausea, vomiting, and abdominal pain. This medication can affect driving or machinery operation, so caution is needed at the beginning of treatment or when increasing dosage. Additionally, this medication can interact with various drugs. Since it is metabolized by CYP3A4 and CYP2D6 enzymes, the effectiveness may change if taken with drugs that inhibit or induce these enzymes. When co-administered with anticholinergic drugs, its effectiveness may decrease due to opposing effects, so caution is necessary. Co-administration with beta-blockers or NSAIDs may increase the risk of side effects. Pregnant or nursing women should generally avoid using this medication, and if absolutely necessary, should consult a doctor. It is not used in children as safety has not been established. In case of overdose, symptoms such as nausea, vomiting, sweating, bradycardia, hypotension, respiratory suppression, and convulsions may occur, and immediate hospital treatment is required. Atropine may be used as an antidote. This medication should be stored out of reach of children, and transferring it to another container is not advisable for quality maintenance.

Serious side effects

Syncope, bradycardia (slow heart rate), heart block, QT interval prolongation, myocardial infarction, heart failure, peptic ulcers, perforated duodenal perforation, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizures, epilepsy, convulsions, intracerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders (motor function disorders, ataxia, movement disorders, dystonia, tremors, involuntary movements, gait disturbances, abnormal posture, speech disorders), neuroleptic malignant syndrome (akinesia, mutism, muscle

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• dizziness
• insomnia
• drowsiness
• fever

This medication should be stored in a tightly closed container to prevent air or moisture from entering. The storage temperature should be maintained between 1 to 30 degrees Celsius. This helps preserve the medication's effectiveness for a longer period.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle