Newmet 500 mg (Metformin Hydrochloride)

Adult dosage

The adult dosage should be determined based on individual drug effects and tolerability, and should not exceed the maximum dose per day. Administer 500 mg 2-3 times daily with meals. Dosage should be increased gradually by 500 mg weekly, and if administering up to 2000 mg, it should generally be divided into two doses in the morning and evening. If exceeding 2000 mg, it should be taken three times a day with meals, and the maximum dose is 2550 mg.

Children's dosage

Children aged 10 years and older and adolescents should be given 500 mg once daily during or after meals. After one week, blood sugar levels should be measured and the dosage adjusted, with the maximum daily dose being 2000 mg.

This drug can cause severe lactic acidosis or hypoglycemia, so caution is required. It should not be administered to patients with moderate or severe renal impairment, or those in acute conditions such as dehydration, serious infections, or acute myocardial infarction. Patients with acute and unstable heart failure, those scheduled for tests using iodinated contrast agents, and patients with hypersensitivity to this drug or biguanide drugs should also avoid using it. Patients with type 1 diabetes or metabolic acidosis, severe infections, or trauma with systemic disorders should temporarily discontinue treatment, and administration should be paused for some time before and after surgery. Patients with liver dysfunction, excessive alcohol consumption, dehydration, gastrointestinal disturbances such as diarrhea or vomiting should avoid using this drug. The use of this drug is also not recommended for patients during pregnancy with placental insufficiency, preeclampsia, or risk of intrauterine growth retardation. Patients with lactose intolerance or genetic metabolic abnormalities should not take this drug. Caution should be exercised when there are irregular meals or insufficient food intake, vigorous exercise, or interactions with other drugs, as there is a risk of lactic acidosis and hypoglycemia. Gastrointestinal symptoms such as diarrhea, nausea, and vomiting are common but mostly temporary. Serious side effects such as lactic acidosis, anemia, blood cell reduction, liver dysfunction, hypoglycemia may occur rarely, so if symptoms appear, immediate consultation with a healthcare professional is required. Regularly monitor kidney function to prevent the accumulation of this drug and the risk of lactic acidosis, especially in elderly patients or those with reduced kidney function. Alcohol can affect the metabolism of this drug and increase the risk of lactic acidosis, so excessive drinking should be avoided during use. Continuously monitor blood sugar control and take appropriate measures if hypoglycemic symptoms occur. When used in conjunction with other hypoglycemic agents, the hypoglycemic effect can be enhanced or reduced, so it is essential to consult with a healthcare professional regarding concomitant medications. Blood sugar control is crucial during pregnancy, and since this drug crosses the placenta, patients planning to become pregnant or those who are pregnant should determine whether to take this drug after consulting with a healthcare professional. If breastfeeding, since this drug is excreted in breast milk, it is advisable to discuss whether to continue breastfeeding or discontinue medication with a healthcare professional. Elderly individuals commonly have reduced kidney function, so dose adjustment and monitoring of kidney function are essential. In cases of overdose, there is a risk of lactic acidosis, so if suspected, immediate medical attention should be sought for appropriate treatment such as blood dialysis. This drug aids in blood sugar control without causing weight gain, but caution is needed when used in children or adolescents. Finally, keep this drug in a safe place out of the reach of children and avoid transferring it to other containers.

Serious side effects

• Lactic acidosis
• severe lactic acidosis
• hypoglycemia
• severe allergic reactions
• severe skin reactions
• liver impairment (jaundice)
• severe edema or urinary abnormalities

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal bloating
• loss of appetite
• indigestion
• constipation
• abdominal pain
• metallic taste
• rash

This drug should be stored in a tightly sealed container that is not exposed to air, and it is recommended to store it at room temperature between 1 and 30 degrees Celsius. This storage condition helps maintain the drug's efficacy for a longer period.

Appearance

White, round film-coated tablet

Package unit

300 tablets/bottle