Roxfense Tablet (Roxoprofen Sodium Hydrate)

Adult dose

1. For indications 1 and 2: Adults should administer 60 mg of Roxoprofen Sodium (anhydrous) orally three times a day. For a one-time dose, 60–120 mg can be taken orally. 2. For indication 3: Adults should administer 60 mg of Roxoprofen Sodium (anhydrous) orally. In principle, it can be taken twice a day, with a maximum daily dose of 180 mg. It is advisable to avoid taking it on an empty stomach.

This medication should be consulted with a doctor or pharmacist before taking, especially for those who regularly consume three or more alcoholic drinks daily, as it may cause gastrointestinal bleeding. This drug may increase the risk of cardiovascular disease, so individuals with a risk of heart disease or stroke should be particularly cautious. During treatment, closely monitor for any cardiovascular symptoms; if any symptoms occur, immediate medical attention is necessary. There is a risk of serious gastrointestinal problems such as bleeding, ulcers, and perforation with this medication. Special care must be taken in older patients or those on prolonged treatment as the risks may increase, thus monitoring gastrointestinal symptoms is essential. Individuals with a history of peptic ulcers, severe blood disorders, liver dysfunction, kidney dysfunction, congestive heart failure, or those allergic to this drug or its components should not take it. Also, individuals who have had allergic reactions to aspirin or other non-steroidal anti-inflammatory drugs, pregnant women in late pregnancy, nursing mothers, and patients with inflammatory bowel disease should not use this drug. Patients with a history of peptic ulcer disease, liver, kidney, or blood disorders, asthmatic patients, hypertensive patients, and the elderly should use caution when taking this medication. Additionally, women in the early or middle stages of pregnancy should seek a doctor’s advice before taking it. If any unusual symptoms like rash, itching, breathing difficulty, abdominal pain, blood in stool, dizziness, liver function abnormalities, renal function abnormalities, or skin rashes occur while taking this medication, stop taking it immediately and consult a doctor. Taking this drug with other non-steroidal anti-inflammatory medications may increase the risk of side effects, so they should not be taken together. Caution is advised as this drug may interact with some diabetes medications, antibiotics, blood pressure medications, diuretics, anticoagulants, lithium, chemotherapy agents, etc.; inform your doctor or pharmacist of all medications you are taking. This medication should not be taken especially during late pregnancy, and it is also considered unsafe during breastfeeding. The safety for children has not been established, and caution is necessary for the elderly due to a higher risk of side effects. Keep this medication out of reach of children, and do not transfer it to other containers.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, shock, anaphylactic-like symptoms, peptic ulcer, perforation, hematemesis, melena, shock, severe skin adverse reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), skin and mucosal syndrome, acute generalized exanthematous pustulosis, fever, difficulty breathing, asthma attacks, liver dysfunction (including jaundice), fulminant hepatitis, acute renal failure, nephrotic syndrome, interstitial nephritis

Mild side effects

• Rash
• itching
• fever
• abdominal pain
• gastrointestinal discomfort
• loss of appetite
• nausea
• vomiting
• diarrhea
• constipation

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. Additionally, it is important to store the drug at room temperature that is not too hot or too cold.

Appearance

White to yellowish round tablets

Package unit

30 tablets/bottle, 300 tablets/bottle