CLOX 200 mg Capsules (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted for each patient. It may be taken with or without food. ○ Adults 1. Osteoarthritis (degenerative arthritis) : Take celecoxib 200 mg once daily, or 100 mg twice daily. 2. Rheumatoid arthritis : Take celecoxib 100 mg or 200 mg twice daily. 3. Ankylosing spondylitis (AS) : Administer celecoxib 200 mg once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg daily. If no effect is observed after 6 weeks at 400 mg daily, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea : The recommended initial dose is celecoxib 400 mg, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose as needed is 200 mg twice daily. ○ Patients with hepatic impairment : For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

Individuals who regularly consume more than a certain amount of alcohol daily should consult a doctor or pharmacist before taking this medication, as there is an increased risk of gastrointestinal bleeding in such cases. Additionally, this medicine may increase the risk of serious cardiovascular issues such as myocardial infarction or stroke. This risk may be heightened depending on the dose and duration of use, so the lowest effective dose should be used for the shortest duration possible. If cardiovascular symptoms such as chest pain, difficulty breathing, weakness, or speech difficulties occur while taking this medication, it is important to inform medical personnel immediately. This medicine can also affect the gastrointestinal tract, potentially leading to serious gastrointestinal issues such as gastric ulcers, bleeding, and perforation. Those who are elderly or have a history of gastrointestinal diseases should exercise additional caution and seek immediate treatment if symptoms such as epigastric pain, dyspepsia, black stools, or vomiting blood occur. This medication should not be administered to patients with a history of certain allergies, severe liver or kidney disease, heart failure, or pregnant or breastfeeding women. During treatment, liver and kidney function, blood tests, etc., should be regularly monitored to detect and manage any abnormalities early. This medication can interact with other drugs, so it is essential to inform the doctor or pharmacist of any other medications being taken, especially when used in combination with antihypertensives, anticoagulants, or antidepressants which require caution. Women planning to become pregnant should consult prior to taking this medication, as it may affect reproductive capacity. Dizziness or drowsiness may occur after taking this medication, so care should be taken when driving or operating machinery. If taking this medication for a prolonged period, regular check-ups should be conducted to monitor for side effects, and medical advice should be sought immediately if abnormal symptoms arise.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of upper and lower gastrointestinal tracts, ulcers, hemorrhage, bronchitis, sinusitis, upper respiratory tract infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusional state, dizziness, muscle tension increase, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, distension, gastric ulcer, dental diseases, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, blistering dermatitis, peripheral edema, facial edema, influenza-like illness, injury, anaphylactic-like reaction, vasculitis, pulmonary embolism, interstitial pneumonia, hepatitis, liver failure, fulminant hepatitis, liver necrosis, photosensitive reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug eruption with eosinophilia and systemic symptoms, acute generalized pustular eruption, exfoliative dermatitis, acute renal failure, hyponatremia, tubulointerstitial nephritis, nephrotic syndrome, minimal change disease glomerulonephritis, menstrual disorders, chest pain, headache, leg cramps, tension increase, sensory decline, migraine, neuralgia, neuropathy, paresthesia, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, loss of taste, hallucinations, epilepsy exacerbation, upper respiratory tract infection, herpes simplex, wound infections, gingivitis, herpes zoster, bacterial infection, fungal infection, soft tissue infection, viral infection, moniliasis, genital moniliasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasms, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, increased serum sodium, increased serum potassium, elevated BUN, elevated CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, loss of appetite, elevated LDH, hypoglycemia, hyponatremia, synovial sac, arthralgia, arthritis, skeletal abnormalities, myalgia, cervical tension syndrome, synovitis, tendinitis, myositis, fractures, tendon rupture, pain in the back, muscle rigidity, reduced hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopathy, anemia, thrombocytopenia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, eosinophilic pneumonia, contact dermatitis, injection site reactions, skin nodules, taste distortion, albuminuria, cystitis, hematuria, dysuria, polyuria, kidney stones, urinary incontinence, urinary tract infections, blurred vision, cataracts, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal dysfunction, acute renal failure, interstitial nephritis

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 15 degrees and 30 degrees Celsius.

Appearance

An opaque white capsule containing a white to off-white powder

Package unit

30 capsules/bottle, 100 capsules/bottle