Piozin 15 mg (Pioglitazone Hydrochloride)

Adult dose

This medication is administered orally once daily regardless of meal. In monotherapy, start at 15 mg once daily and may increase to 30 mg once daily as needed. In combination therapy, administer 15 mg once daily when used with sulfonylureas, metformin, or insulin. The maximum recommended dosage should not exceed 30 mg once daily.

Child dose

The safety and effectiveness in children under 18 years of age have not been established, hence it is not recommended for use.

This drug is used for the treatment of type 2 diabetes and requires insulin to exert its blood sugar-lowering effect. It may worsen or newly induce heart failure, so it should not be used in patients with heart failure. If sudden weight gain, shortness of breath, or edema occurs during treatment, immediate medical attention should be sought. As it can cause fluid retention, leading to edema or exacerbation of heart failure, special caution should be exercised in patients with edema or heart disease. Patients with active bladder cancer or a history of bladder cancer should not use this medication, and if hematuria or urinary disorders arise during treatment, they should notify their physician immediately. Patients with poor liver function should have regular liver function tests before and during treatment, and should seek medical attention if signs of liver damage appear. Hypoglycemic symptoms may occur during treatment; particular caution should be observed when it is taken with insulin or sulfonylureas due to the risk of hypoglycemia. Weight gain and edema can occur frequently, therefore it is important to regularly monitor weight and edema status. In premenopausal women, this drug may promote ovulation and increase the possibility of pregnancy; hence, appropriate contraception should be utilized. Elderly patients, those with impaired renal or liver function, and patients with cardiovascular disease should be managed more cautiously during treatment with this medication. Pregnant or potentially pregnant women and breastfeeding mothers should avoid using this medication or consult a healthcare professional. Due to potential drug interactions, it is crucial to inform your physician or pharmacist of any other medications being taken. Regular blood sugar and liver function tests should be performed during the treatment period, and any unusual symptoms should be reported to healthcare personnel immediately. This medication has not been established for safety and efficacy in children and is therefore not recommended for use in this population. In case of overdose, appropriate treatment should be administered according to symptoms, and medications should be kept out of reach of children.

Serious side effects

Congestive heart failure, worsening of heart failure, severe edema (generalized edema, pitting edema, peripheral edema), cardiac dysfunction, myocardial infarction, cardiovascular abnormalities, severe liver abnormalities (liver failure, liver damage, worsening of liver disease), jaundice, severe allergic reactions (including hives), severe skin reactions (severe rash, blisters, peeling skin, mucosal pain), severe respiratory problems (shortness of breath, difficulty breathing, asthma attack), severe neurological symptoms

Mild side effects

• Upper respiratory tract infection
• headache
• sinusitis
• muscle pain
• pharyngitis
• abdominal distension
• weight gain
• hypoglycemia
• urinary tract infection
• back pain

This medication is sensitive to light and should be stored in a special container that prevents light exposure. Additionally, avoid humid environments, and it is best to store it at a temperature between 15 to 30 degrees Celsius, preferably around 25 degrees.

Appearance

White round tablet

Package unit

30 tablets/bottle, 100 tablets/bottle