Artpe Tablets 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bed. For the first 4 to 6 weeks, maintain a dosage of 5 mg, and after evaluating clinical response, it may be increased to 10 mg. When increasing to 10 mg per day, caution should be taken regarding gastrointestinal adverse reactions. Women over 85 years of age who are underweight should not exceed 5 mg per day, and careful monitoring is necessary.

Child dose

There is no experience regarding the use in children.

This medication contains Donepezil Hydrochloride Hydrate as its active ingredient and is used for improving symptoms of Alzheimer's disease. This medication should not be administered to certain patients. For example, individuals with allergies to this medication or its ingredients, pregnant women or women who may become pregnant, breastfeeding women, and individuals with lactose intolerance or specific genetic metabolic disorders should not take this medication. Patients with heart disease or heart conduction disorders should be cautious when using this medication, as there is a possibility of heart problems such as bradycardia or arrhythmia. Individuals taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should use this medication with caution due to the risk of gastrointestinal bleeding or exacerbation of ulcers. Patients with a history of asthma or obstructive pulmonary disease should be careful, as symptoms may worsen due to bronchoconstriction and increased mucus secretion. Patients with extrapyramidal disorders such as Parkinson's disease may experience worsening of their symptoms. Moreover, individuals allergic to the coloring agent Yellow No. 5 included in this medication should also be careful. This medication can cause various adverse effects, and in severe cases, heart problems, gastrointestinal bleeding, liver dysfunction, neurological issues, muscle problems, difficulty breathing, pancreatitis, kidney failure, and sudden death have been reported. Commonly, symptoms such as nausea, vomiting, diarrhea, headache, dizziness, insomnia, and fatigue may occur. Regular evaluation of therapeutic effects and side effects should be conducted during the use of this medication, and if there is no effect or if side effects are severe, the medication may be discontinued. This medication can affect heart rhythms, so individuals with a history of heart diseases or abnormal ECGs require special monitoring and investigation. Additionally, this medication may enhance gastric acid secretion and increase gastrointestinal motility, potentially worsening symptoms of peptic ulcers, so caution is advised for those with a history of gastrointestinal diseases. Caution is also needed for driving or operating machinery due to the possibility of dizziness or fatigue from taking this medication. Pregnant or breastfeeding women should generally avoid using this medication, and if necessary, consulting a specialist is essential. The safety for use in children has not been established, so it should not be used in this population. This medication is metabolized in the liver, hence patients with impaired liver function should be cautious, and interaction with other medications is possible, so any current medications should be disclosed to the doctor. In cases of overdose, symptoms such as nausea, vomiting, severe muscle weakness, and difficulty in breathing may occur, and immediate medical attention is needed. This medication should be kept out of the reach of children and should not be transferred to other containers.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reactions), high fever with severe rash, blisters, skin peeling, pain in oral/ocular mucosa (severe skin reactions), shortness of breath or difficulty in breathing, asthma attacks, respiratory issues accompanied by cough and fever, yellowing of the skin or eyes (jaundice), severe lethargy (liver issues), sudden and very severe headache

Mild side effects

Nausea, vomiting, diarrhea, loss of appetite, insomnia, drowsiness, dizziness, headache, fatigue, tremors, sweating, skin rash, itching, muscle pain, incontinence, urinary disorders, edema, anxiety, hallucinations, aggressive behavior, confusion, delusions, drowsiness, increased blood pressure, palpitations, hypertension, hypotension, atrial fibrillation, QT interval prolongation on ECG, motor impairment, ataxia, voice changes, blood abnormalities (anemia, leukopenia, thrombocytopenia, etc.), abdominal pain

This medication should be stored in a tightly closed container to prevent air or moisture ingress. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius. Proper storage will help preserve the effectiveness of the medication.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle