Frost Tablet (Limaprost Alpadex)

Adult dose

1. For improvement of ischemic symptoms such as ulcers, pain, and coldness caused by thromboangiitis obliterans (Buerger’s disease), the usual adult dose is 2 tablets orally 3 times daily. 2. For improvement of subjective symptoms (lower-limb pain and numbness) and walking ability caused by acquired lumbar spinal canal stenosis (in patients with normal SLR test results and bilateral intermittent claudication), the usual adult dose is 1 tablet orally 3 times daily. The dose may be adjusted appropriately according to age and symptoms.

This medication should not be used by women who are pregnant or may become pregnant. This medication contains lactose and should not be administered to patients with genetic conditions such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. Caution should be exercised in patients with a tendency to bleed or those taking antiplatelet agents, thrombolytics, or anticoagulants. During the use of this medication, hypersensitivity reactions such as rash or itching may occur, and if these symptoms appear, it should be discontinued immediately. Bleeding may rarely occur, so symptoms should be closely monitored, and if abnormalities arise, administration should be stopped. Gastrointestinal symptoms such as diarrhea, nausea, abdominal discomfort, abdominal pain, loss of appetite, heartburn, vomiting, and abdominal bloating may occur. Liver function abnormalities may occur, so it is advisable to periodically check liver enzymes (AST, ALT). Cardiovascular symptoms such as palpitations, cyanosis of hands and feet, and hypotension may occur. Headaches, facial flushing, dizziness, heat sensation, general fatigue, edema, glandular swelling, tremors, hirsutism, and anemia may occur rarely. Patients with lumbar spinal stenosis should observe the progression of symptoms to decide whether to continue use, and for severe cases requiring surgery, the effectiveness of this medication is uncertain. Safety during pregnancy has not been established, and contraction effects have been reported in animal studies, so pregnant women or those who may become pregnant should not take this medication. Safety in children has not been confirmed, so it is advisable not to use it in children. In elderly patients, caution should be taken as physiological function may be decreased, and the dosage should be reduced accordingly.

• Rash
• itching
• bleeding
• diarrhea
• nausea
• abdominal discomfort
• abdominal pain
• loss of appetite
• heartburn
• vomiting

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

White round tablets

Package unit

84 tablets/Alu-Alu (21 tablets/Alu-Alu X4)