Pexot 40 mg (Febuxostat)

Adult dosage

1. Adults Administer 40mg or 80mg once daily, regardless of meals. This medicine acts very rapidly; therefore, recheck serum uric acid levels after 2 weeks. The treatment goal is to lower and maintain serum uric acid levels below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dose adjustment is required for patients with mild to moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance less than 30mL/min). 3. Patients with hepatic impairment No special dose adjustment is required for patients with mild to moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

Caution is required when administering this drug to patients with cardiovascular diseases, as it may increase the risk of cardiovascular mortality. Patients with a history of cardiovascular disease should avoid using this medication if alternate treatments are available. Patients who are allergic to the components or excipients of this drug, patients taking certain immunosuppressants (mercaptopurine, azathioprine), and those with lactose intolerance or related genetic disorders should not take this medication. Patients with a history of liver disease or thyroid dysfunction should have their liver and thyroid functions regularly monitored while using this drug. Patients with heart failure, ischemic heart disease, organ transplant recipients, and patients with severely increased uric acid production should also use this medication with caution. This drug may cause various side effects such as liver dysfunction, diarrhea, headache, rash, dizziness, myalgia, etc., so it is important to consult with healthcare professionals if symptoms occur. This drug should not be initiated during acute gout attacks, and concurrent preventive medication may be needed as gout attacks can worsen in the early stages of treatment. This drug may have central nervous system side effects such as drowsiness or dizziness, so caution is needed when driving or operating machinery. This medication can interact with certain drugs, so be sure to inform healthcare professionals of any other medications being taken. It is recommended that pregnant or breastfeeding women do not take this medication. There is no experience with children under 18 years old, so they should not be administered this drug. There are no specific incidents reported for overdose, but appropriate treatment is required according to symptoms. Store out of reach of children, and no special storage conditions are required.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, arthralgia, limb pain, gout, myalgia, pruritus, dyspnea, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, ECG abnormalities, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, bloating, increased bowel frequency, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, melena, oral ulcers, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, emotional disturbances, gait disorders, influenza-like symptoms, mass, pain, thirst, cholelithiasis, diabetes mellitus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, reduced appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramps, muscle fasciculations, muscular stenosis, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance disorders, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, hyposmia, heat stroke, drowsiness, mental disorder, migraine, sensory disturbances, sleepiness, transient ischemic attack, tremors, agitation, anxiety, depression, insomnia, excitability, decreased libido, nervous irritability, panic attacks, personality changes, hematuria, nephrolithiasis, frequent urination, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, mastalgia, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, excessive nasal secretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory tract infection, alopecia, angioedema, dermatitis, leukoderma, purpura, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechiae, photosensitivity, itching, purpura, skin discoloration, pigmentation changes, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, prolonged activated partial thromboplastin time, increased creatinine, decreased bicarbonate, increased sodium, EEG abnormalities, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, increased creatinine, increased blood urea, increased blood urea/creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased leukocyte count, decreased leukocyte count, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, positive urinary leukocytes, positive urinary protein, contusions, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, severe allergic reaction, hypersensitivity reaction, eosinophilia, drug reactions with systemic symptoms, liver failure, jaundice, liver dysfunction, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly closed container to prevent air or moisture exposure. Additionally, avoid storing the drug in extremely hot or cold places, and it is best to keep it at a normal room temperature between 1 to 30 degrees Celsius.

Appearance

White to light yellow round film-coated tablet

Package unit

30 tablets/bottle