Unirabeph Tablet 20 mg (Rabeprazole Sodium)

Adult dose

Gastric Ulcer, Duodenal Ulcer: Administer 10 mg by mouth once daily as Rabeprazole Sodium. Depending on symptoms, 20 mg may be administered once daily. Treatment duration for gastric ulcer is up to 8 weeks, and for duodenal ulcer is up to 6 weeks. Erosive or Ulcerative Gastroesophageal Reflux Disease: Administer 10 mg or 20 mg once daily for 4 to 8 weeks. If not treated, may additionally administer 10 mg or 20 mg for another 8 weeks.

This medication should not be used in patients with allergies to specific ingredients or a history of hypersensitivity to benzimidazoles. Furthermore, when used in combination with amoxicillin or clarithromycin for the eradication of Helicobacter pylori, it should be avoided in patients with hypersensitivity to penicillin or macrolide antibiotics. It should also be avoided in patients taking specific drugs such as terfenadine, cisapride, pimodipine, astemizole, atazanavir, and rilpivirine. Pregnant or breastfeeding women should not take this medication. Patients with impaired liver function, the elderly, and those with a history of drug hypersensitivity should use this medication cautiously. This medication may cause hypersensitivity reactions such as skin rash, urticaria, and itching; if these symptoms occur, use should be stopped immediately. Regular blood tests are required as there may be changes in red or white blood cell counts. Periodic liver function tests should be conducted as signs of liver dysfunction may appear, and treatment should be stopped if abnormalities are found. Cardiovascular adverse reactions have been reported, so caution is required in cases of hypertension, myocardial infarction, or arrhythmias. Various symptoms such as diarrhea, abdominal pain, nausea, and vomiting may occur, so consult a doctor if such symptoms arise. Neurological symptoms may include headache, insomnia, anxiety, and dizziness; thus, caution is advised. Respiratory symptoms such as cough or dyspnea may also occur, and rarely, interstitial pneumonia may develop, requiring immediate medical attention if fever and dyspnea appear. Musculoskeletal and skin-related side effects may also occur; therefore, consult a healthcare professional if any unusual symptoms arise. This medication suppresses gastric acid secretion and may increase the risk of gastrointestinal bacterial infections, so caution is needed for long-term use. There may be effects such as drowsiness when driving or operating machinery. Interactions with other medications may occur, especially with warfarin, methotrexate, and antibiotics; consult a doctor when using these in combination. This medication should not be used during pregnancy and breastfeeding, and caution should be exercised in the elderly due to the potential for increased side effects from decreased liver function. Safety in children has not been established, so it is advisable not to use it in this population. There are no specific antidotes for overdose, but treatment and supportive therapy according to symptoms are needed. Tablets should not be chewed or crushed and should be swallowed whole, and should be kept out of reach of children. This medication may mask symptoms of malignant tumors, so if malignancies such as gastric cancer are suspected, it must be confirmed before use. During prolonged treatment, especially for more than one year, regular monitoring for adverse effects is necessary. There may be malabsorption of vitamin B12 when taking this medication, so caution is required for long-term use. Autoimmune diseases such as skin and systemic lupus erythematosus may develop or worsen, so consult a healthcare professional immediately if related symptoms occur. If kidney function impairment is suspected, treatment should be stopped, and appropriate measures should be taken.

Serious side effects

Urticaria, severe swelling, tightness in the chest, difficulty breathing, severe rash with fever, blisters, skin peeling, pain in the mucous membranes of the mouth/eyes, yellowing of the skin or eyes (jaundice), generalized malaise, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, numbness, significantly reduced urine output, severe edema, elevated blood pressure, severe allergic reactions, severe skin reactions, respiratory problems, liver

Mild side effects

• Rash
• itching
• reduction in red blood cells
• reduction in white blood cells
• increase in white blood cells
• increase in eosinophils
• increase in neutrophils
• decrease in lymphocytes
• anemia
• petechiae

This medication may be sensitive to air or moisture, so it must be stored in a tightly closed container. Additionally, it is important to store it at room temperature between 1 degree and 30 degrees Celsius to maintain its effectiveness.

Appearance

Light yellow round enteric-coated tablet

Package unit

28 tablets/box [14 tablets/Alu Alu packaging x 2]