Pioglitazone Tablet (Pioglitazone Hydrochloride)

Adult dosage

This drug is administered orally once a day, regardless of meals. It can be started at a dose of 15 mg once daily as monotherapy, and if there is insufficient effect, the dose can be increased to 30 mg once daily. When used in combination with sulfonylureas, metformin, or insulin, the initial dose is also 15 mg once daily, and the maximum recommended dose should not exceed 30 mg once daily.

Children's dosage

There is no experience using in children under 18 years; therefore, administration is not recommended.

This drug is used for the treatment of Type 2 diabetes and helps improve insulin resistance and control blood sugar levels. During the use of this drug, caution should be taken regarding heart function. In some patients, this drug may induce or worsen heart failure, so if symptoms such as weight change, shortness of breath, or swelling occur, immediate consultation with a physician is necessary. Patients with heart failure or a history of heart failure should not take this drug. Additionally, this drug may cause fluid retention that can stress the heart, so it should be used with increased caution in patients with cardiovascular disease. During the use of this drug, if symptoms related to the bladder, such as hematuria, urinary disorders, or urgency, appear, the physician should be informed immediately to rule out bladder cancer. This drug should not be administered to patients with severe liver or kidney impairment, and regular liver function and kidney function tests should be performed. Women who are pregnant or may become pregnant should not take this drug, and premenopausal women should use appropriate contraceptive methods due to the risk of ovulation stimulation leading to pregnancy. This drug may increase the risk of hypoglycemia when combined with other hypoglycemic agents or insulin, so dose adjustments may be necessary when used in combination. Furthermore, this drug can cause weight gain and edema, so careful monitoring of weight changes and edema symptoms is advised. Elderly patients or those with decreased kidney and liver function should exercise additional caution when using this drug, and regular health checks are necessary. In case of overdose, even if special symptoms are absent, immediate consultation with healthcare professionals for appropriate action is advised. This drug has not been shown to be safe and effective in children; therefore, it should not be used in this population.

Serious side effects

Congestive heart failure, symptoms and signs of heart failure (including excessive and rapid weight change, shortness of breath, swelling), worsening heart failure, myocardial infarction, stroke, serious cardiac adverse reactions, gross hematuria, urinary disorders, urgency, bladder cancer, liver failure, liver dysfunction (including jaundice symptoms), fatal and non-fatal liver failure, severe edema, hospitalization due to hypoglycemia, severe neurological symptoms (headache, seizures, confusion, visual disturbances

Mild side effects

• Upper respiratory infection
• headache
• sinusitis
• muscle pain
• pharyngitis
• abdominal distension
• weight gain
• hypoglycemia
• urinary tract infection
• low back pain

This drug is sensitive to light and should be stored in a tightly closed container protected from light. It should be kept in a cool place away from high humidity at temperatures between 15 and 30 degrees Celsius, preferably around 25 degrees.

Appearance

White round tablet

Package unit

30 tablets/bottle, 300 tablets/bottle