Ronaqoo Tablets 2mg (Brotizolam)

Adult dose

Adults: Administer 4 mg per dose twice daily after meals, increasing the dose gradually. The maintenance dose is 8~16 mg per day, divided into 2 doses taken after meals. As the absorption of this drug is readily affected by food, it must be taken after meals. Carefully monitor each patient and adjust the dose to the minimum required; do not exceed the maximum daily dose of 24 mg.

This medication may increase the mortality rate in elderly patients with dementia, so caution is advised. In patients at risk for stroke, there may be an increased risk of cerebrovascular events, hence it should be used with caution. During the course of this medication, thrombosis may occur, so it is important to ascertain if there are risk factors for thrombosis and to take preventive measures. Patients in a stupor state, those on central nervous system depressants, patients taking certain antifungal or HIV medications, and those allergic to any component of this drug should not receive this medication. Patients with lactose intolerance or certain genetic metabolic disorders should also avoid taking this drug. Patients with cardiovascular diseases, Parkinson's disease, epilepsy, suicide risk, liver impairment, diabetes, elderly patients, underweight infants and children, pregnant women, and nursing mothers should be careful when using this medication. This drug can cause various side effects such as tremors, movement disorders, insomnia, drowsiness, anxiety, and changes in blood pressure, so symptoms should be closely monitored. In severe cases, life-threatening adverse reactions such as neuroleptic malignant syndrome, tardive dyskinesia, paralytic ileus, and antidiuretic hormone secretion abnormality syndrome may occur, and immediate consultation with medical personnel is necessary. Drowsiness or decreased concentration may occur during treatment with this medication, so driving or operating hazardous machinery should be avoided. Due to drug interactions, taking this medication with certain drugs may enhance its effects or increase the risk of side effects, thus it's imperative to inform healthcare professionals about any current medications being taken. Women who are pregnant or breastfeeding should refrain from taking this medication unless absolutely necessary and should consult with a doctor. The safety of this drug in children or infants has not been established, so consultation with a specialist is advised before use. This drug must be taken after meals, as taking it on an empty stomach may reduce efficacy or cause rapid fluctuations in blood concentration.

Tremors, akinesia, excessive salivation, Parkinson's syndrome, inability to sit still, insomnia, increased prolactin, movement disorders, drowsiness, anxiety, restlessness, irritability, neuroleptic malignant syndrome, mutism, severe muscle rigidity, dysphagia, tachycardia, blood pressure fluctuations, sweating, consciousness disorders, dyspnea, circulatory collapse, dehydration, acute kidney injury, tardive dyskinesia, involuntary facial muscle movements, paralytic ileus, decreased appetite, nausea, vomiting, severe diarrhea, abdominal distension, lethargy, syndrome of inappropriate antidiuretic hormone secretion, hyponatremia, hypotonicity, urine sodium hyperexcretion, hyperuricemia, seizures, rhabdomyolysis, myalgia, feeling weak, elevated CK, elevated serum myoglobin, elevated urinary myoglobin, agranulocytosis, leukopenia, liver dysfunction, elevated AST, elevated ALT, elevated γ-GTP, elevated ALP, elevated bilirubin, hyperglycemia, diabetic ketoacidosis, diabetic coma, eosinophilia, drug reaction with systemic symptoms, rash, eczema, pruritus, hypotension, orthostatic hypotension, hypertension, ECG abnormalities, tachycardia, bradycardia, arrhythmia, ventricular ectopy, loss of ectopy, palpitations, reduced heart rate, akinesia, dysarthria, dysphagia, involuntary oral and limb movements, dystonia, rigidity, facial spasms, pharyngeal spasm, uterine spasms, ocular motor seizures, opisthotonos, control disorders, blurred vision, constipation, decreased appetite, increased appetite, diarrhea, epigastric pain, abdominal pain, gastrointestinal disorders, cheilitis, menstrual irregularities, galactorrhea, ejaculation disorders, gynecomastia, erectile dysfunction, dysuria, urinary retention, urinary incontinence, pollakiuria, dizziness, vertigo, dull headache, headache, excitement, numbness of hands and feet, suicide attempts, over-sedation, over-inhibition, depression, hallucinations, auditory hallucinations, delusions, paranoid delusions, sleep disorders, abnormal behavior, hyperactivity, EEG abnormalities, manic states, consciousness disorders, emotional abnormality, speech disorders, loquacity, tension, seizures, leukocytosis, neutrophilia, lymphocytopenia, erythrocytosis, anemia, erythrocytopenia, hemoglobin decrease, hematocrit decrease, thrombocytosis, thrombocytopenia, atypical lymphocytes, generalized malaise, thirst, feeling weak, edema, water intoxication, hair loss, sweating, fever, weight gain, weight loss, chest pain, cough, facial edema, aspiration pneumonia, hypothermia, elevated CK, increased triglycerides, elevated serum cholesterol, increased serum insulin, increased serum phospholipids, increased blood sugar, elevated BUN, decreased serum total protein, increased serum potassium, decreased serum potassium, decreased serum sodium, positive urine protein, positive urine urobilinogen, positive urine glucose, thromboembolism, pulmonary embolism, deep vein thrombosis, epidermolysis necrosis, lethargy

This medication should be stored in a tightly closed container to prevent air and moisture from entering, at room temperature between 1 degree and 30 degrees Celsius. Storing it this way will ensure the safety and effectiveness of the medication.

Appearance

White round tablet

Package unit

30 tablets/bottle, 100 tablets/bottle