Wyhyaluronic Acid Sodium Injection

Adult administration

As sodium hyaluronate, administer 25mg once a week for 5 consecutive weeks into the knee joint or shoulder joint (shoulder joint cavity, subacromial bursa, or biceps tendon sheath), adjusting the number of doses appropriately based on symptoms.

This medication should not be used in patients who have had allergic reactions to this medication or its components. Since this is a drug injected directly into the joint, it is safer not to administer it if there are skin diseases or infections at the injection site. Patients with liver dysfunction or a history of liver disease need to be cautious as liver function test results may become abnormal upon using this medication. Patients allergic to avian proteins should not use this medication. When using this medication, serious allergic reactions such as shock can occur, so the patient's condition should be closely monitored, and administration should be stopped immediately if unusual symptoms appear. Allergic symptoms may manifest as swelling, redness, rash, urticaria, or itching in the face or eyelids, and if such symptoms occur, treatment should be stopped and appropriate care should be sought. At the injection site, temporary pain, swelling, redness, warmth, severe pressure, or bruising may occur, and symptoms such as nausea, vomiting, fever, or headache may also appear. In cases of severe arthritis, inflammation may worsen, so it is better to use this medication after the inflammatory symptoms have subsided. After administration, stabilizing the injection site and avoiding excessive movement can help relieve pain. If the medication leaks outside the joint, pain may worsen, making it important to administer it precisely into the joint. Caution should be exercised as inflammation may temporarily worsen in patients with inflammatory arthritis such as rheumatoid arthritis or gouty arthritis. It is advisable to avoid vigorous exercise such as jogging or tennis and prolonged weight-bearing activities within 48 hours after administration. Safety and efficacy have not been established when used in conjunction with other intra-articular injectables, so they should not be combined. Women who are pregnant or may become pregnant should carefully consider the benefits and risks of using this medication, and nursing mothers should avoid breastfeeding as the medication may be passed into breast milk. Safety for pediatric use has not been sufficiently established, so it should be used cautiously only when necessary. Older adults may have reduced physiological function; therefore, care should be taken when using this medication. Aseptic conditions must be maintained during injection, and continued administration is limited to a maximum of 5 times if symptoms do not improve. If there is excess joint fluid, it is advisable to drain it before administering this medication. This medication is not intended for intravenous injection or ophthalmic use. Due to its high viscosity, care should be taken in selecting syringes and needles, and the ampoule should be shaken to ensure the medication gathers before slowly aspirating it into the syringe. When cutting the ampoule, it is safer to wipe it with a clean cloth to prevent contamination. Caution should also be taken as the medication may precipitate if used with a sterilizing disinfectant. This medication is for single use only, and any remaining medication should be discarded after opening.

Serious side effects

Urticaria

Mild side effects

• Swelling (facial, eyelid, etc.)
• facial flushing
• rash
• itching
• pain
• enlargement
• edema
• redness
• warmth
• severe local pressure

This medication should be stored in a sealed container to prevent contact with air, preferably at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the medication’s efficacy.

Appearance

A colorless, transparent viscous liquid filled in a glass vial sealed with rubber stoppers at both ends (part of a pre-filled syringe system)

Package unit

2.5 milliliters × 10 vials