Roxonix Tablets (Sodium Loxoprofen Hydrate)

Adult dose

1. For indications 1 and 2: ○ Adults: Administer 60 mg of loxoprofen sodium (anhydrous) orally three times a day. For a single dose, administer 60-120 mg orally. 2. For indication 3: ○ Adults: Administer 60 mg of loxoprofen sodium (anhydrous) orally. In principle, it can be administered twice a day, with a maximum daily dosage of 180 mg. Avoid taking on an empty stomach.

This medication may cause gastrointestinal bleeding in individuals who regularly consume more than three alcoholic beverages per day, so it is essential to consult a doctor or pharmacist. It may also increase the risk of cardiovascular complications such as myocardial infarction and stroke in patients with cardiovascular diseases or risk factors, so careful observation of symptom emergence is required. Serious gastrointestinal side effects including gastrointestinal bleeding, ulcers, and perforations may occur, and if any symptoms of gastrointestinal bleeding appear during treatment, immediate consultation with medical professionals is necessary. This medication should not be used in patients with specific conditions such as peptic ulcers, severe liver disease, renal impairment, or heart failure, and those allergic to aspirin or other non-steroidal anti-inflammatory drugs should avoid administration. Special caution is advised when used by elderly patients, those with hypertension, blood clotting disorders, pregnant women in the early and middle stages, and asthma patients, and if adverse reactions occur, the medication should be stopped immediately and appropriate measures taken. If symptoms such as rash, itching, difficulty breathing, low blood pressure, gastrointestinal bleeding, abdominal pain, headache, dizziness, abnormal liver functions, or decreased renal function occur, notify medical professionals immediately. This medication may interact with other non-steroidal anti-inflammatory drugs, anticoagulants, diuretics, lithium, methotrexate, etc., so patients taking other medications must inform their doctor. It should not be used during late pregnancy due to potential risks to the fetus, and it is also safe to avoid administration during breastfeeding. Safety in children has not been established; hence, it is advised not to administer it to children. This medication should be used at the minimum effective dose for the shortest duration possible, and regular blood tests and liver and kidney function assessments are recommended if used for extended periods. It should be stored out of reach of children and care should be taken not to transfer it to other containers.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, shock, symptoms resembling anaphylaxis, gastrointestinal bleeding (hematemesis, melena, blood in stool), perforation, liver dysfunction (including jaundice), acute renal failure, interstitial nephritis, hepatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), polymorphic erythema, acute generalized exanthemous pustulosis, aseptic meningitis, angioedema, facial swelling (periorbital edema, oral edema), small intestine and colon

Mild side effects

• Rash
• itching
• fever
• abdominal pain
• discomfort in the stomach
• loss of appetite
• nausea
• vomiting
• diarrhea
• constipation

This medication may be sensitive to air and moisture, so it must be stored in a tightly sealed container. Additionally, it should be kept away from extremely hot or cold places, ideally stored at room temperature between 1 and 30 degrees Celsius.

Appearance

White round tablet

Package unit

30 tablets/bottle, 300 tablets/bottle